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Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00872 | -- | $-- | Inquiry |
Gemcitabine-O-Si(di-iso)-O-Mc is a synthetic derivative of the antineoplastic agent gemcitabine, meticulously crafted to elevate its efficacy and delivery. Here are four key applications of this innovative compound:
Chemotherapy: Gemcitabine-O-Si(di-iso)-O-Mc plays a pivotal role in chemotherapy regimens targeting a spectrum of cancers like pancreatic, lung, and breast cancer. Its advanced delivery system ensures optimized drug concentrations reach malignant cells, amplifying therapeutic effectiveness. This tailored approach not only fosters superior treatment outcomes but also holds the promise of mitigating adverse effects linked to conventional gemcitabine therapy.
Targeted Drug Delivery: By transforming gemcitabine into Gemcitabine-O-Si(di-iso)-O-Mc, researchers unlock the potential for tailored drug delivery systems. These systems precisely guide the drug to cancerous cells, minimizing harm to healthy tissues. Such targeted precision not only augments therapeutic efficacy but also diminishes systemic toxicity.
Drug Combination Studies: Exploration of Gemcitabine-O-Si(di-iso)-O-Mc in synergy with other chemotherapeutic agents unveils the potential for enhanced anticancer effects. Combining this derivative with complementary drugs may synergistically elevate overall efficacy and surmount resistance mechanisms.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
