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MC-VC-PABC-SP 141 is part of an antibody-drug conjugate, which is composed of a potent MDM2 inhibitor SP 141 and a degradable ADC linker MC-VC-PABC.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01473 | -- | $-- | Inquiry |
MC-VC-PABC-SP 141, a crucial linker molecule in targeted drug delivery, especially in the realm of antibody-drug conjugates (ADCs), is a versatile compound with diverse applications. Here are four key applications of MC-VC-PABC-SP 141:
Antibody-Drug Conjugates (ADCs): Positioned at the forefront of innovation, MC-VC-PABC-SP 141 assumes a critical role in establishing sturdy bonds between antibodies and cytotoxic drugs within ADCs. This linker guarantees the drug's steadfast attachment during circulation, ensuring effective release within targeted cancer cells. This precision not only minimizes off-target effects but also amplifies the therapeutic efficacy of cancer treatments dramatically.
Targeted Cancer Therapy: In the realm of targeted cancer therapy, MC-VC-PABC-SP 141 emerges as a beacon of specificity and reduced toxicity. By coupling potent chemotherapeutic agents with monoclonal antibodies through this linker, drugs are ferried directly to cancer cells, sparing healthy tissues from harm. This targeted approach maximizes the annihilation of malignant cells while mitigating the adverse effects associated with traditional chemotherapy regimens significantly.
Protease-Triggered Drug Release: The ingenious design of MC-VC-PABC-SP 141 incorporates a unique mechanism where drug liberation hinges on tumor-associated proteases. The cleavable linker maintains stability in the bloodstream but relinquishes its payload upon encountering specific enzymatic actions in the tumor microenvironment. This strategic feature enables controlled and localized drug release, ultimately refining the therapeutic index and optimizing treatment outcomes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
