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2',3'-cGAMP-C2-PPA (45), a cyclic dinucleotide, is a STING agonist (US20210015941A1). 2',3'-cGAMP-C2-PPA is a part of antibody-linker conjugate for ADC (drug-linker conjugate for ADC), which can be used to synthesize antibody conjugates for targeted cancer research.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01454 | -- | $-- | Inquiry |
2,'3'-cGAMP-C2-PPA is a synthetic analog of cyclic GMP-AMP (cGAMP), an important molecule in the study of immune response and cellular signaling. Here are some key applications of 2',3'-cGAMP-C2-PPA:
Immunotherapy Research: 2',3'-cGAMP-C2-PPA is used to activate the STING (Stimulator of Interferon Genes) pathway, which plays a critical role in innate immunity. By stimulating this pathway, researchers can explore new strategies for cancer immunotherapy, infectious disease treatments, and autoimmune disorders. This molecule helps in understanding how to modulate immune responses to enhance therapeutic outcomes.
Vaccine Development: In vaccine research, 2',3'-cGAMP-C2-PPA serves as an adjuvant to enhance the efficacy of vaccines. By promoting a stronger and more durable immune activation, it can improve the body's defense against various pathogens. This application is particularly valuable in developing vaccines for hard-to-target diseases like HIV and emerging infectious agents.
Antiviral Research: 2',3'-cGAMP-C2-PPA is studied for its potential to boost antiviral defenses by stimulating interferon production. This can inhibit the replication of viruses such as influenza, herpes simplex virus, and others. Researchers use this compound to identify new antiviral strategies and develop treatments that can effectively control viral infections.
Cellular Signaling Studies: 2',3'-cGAMP-C2-PPA is an important tool in the study of cGAMP-mediated signaling pathways. By elucidating how these pathways regulate immune responses and other cellular processes, scientists can uncover new therapeutic targets. This knowledge is essential for developing drugs that can precisely manipulate cellular signaling for therapeutic benefit.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
