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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00461 | -- | $-- | Inquiry |
4-succinimidyl-oxycarbonyl-α-(2-pyridyldithio)toluene, often referred to as SPDP, serves as a versatile cross-linking reagent with multifaceted applications in diverse biochemical settings. Here are four key applications of SPDP, presented with high perplexity and burstiness:
Protein-Protein Conjugation: SPDP emerges as a pivotal tool for covalently joining distinct proteins, opening avenues to investigate intricate protein-protein interactions. Through the establishment of steadfast disulfide bonds between proteins, researchers orchestrate functional protein complexes tailored for biochemical assays. This method is indispensable in unraveling the nuanced functional dynamics of protein associations within cellular processes.
Antibody Labeling: Delving into the realm of antibody labeling, SPDP plays a pivotal role in affixing antibodies with a spectrum of tags like enzymes, fluorescent dyes, or radioactive labels. This strategic maneuver enables the creation of antibody conjugates instrumental in diagnostic assays, flow cytometry, and imaging modalities. The precision inherent in the conjugation process upholds the biological activity of the antibody, ensuring the generation of dependable results.
Drug Delivery Systems: Embarking on the frontier of targeted drug delivery, SPDP facilitates the construction of tailored drug delivery systems by tethering therapeutic agents to targeting molecules, such as antibodies or peptides. This innovative approach bolsters the precise conveyance of drugs to specific cells or tissues, enhancing therapeutic efficacy while mitigating side effects. Such targeted systems prove exceptionally valuable in oncology and other domains of precision medicine.
Surface Immobilization: Leveraging the prowess of SPDP, researchers can immobilize biomolecules on solid substrates for a myriad of bioanalytical and biosensing endeavors. By affixing proteins, peptides, or other species onto surfaces, scientists fashion biosensors indispensable for detecting specific analytes. This capability is pivotal in realms spanning diagnostics, environmental surveillance, and biotechnological exploration, fostering the development of high-throughput screening methodologies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
