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H-D-trans-Hyp-OMe HCl is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01926 | -- | $-- | Inquiry |
H-D-trans-Hyp-OMe HCl (Hydroxyproline methyl ester hydrochloride) is a modified form of the amino acid hydroxyproline, with a methoxy group attached to the hydroxyl group of the proline side chain. This modification provides increased stability and solubility, making it a valuable building block in peptide synthesis and protein engineering. Hydroxyproline is a key component of collagen and plays a crucial role in the structural integrity of connective tissues. As such, H-D-trans-Hyp-OMe HCl is used in the synthesis of peptides and peptidomimetics designed to mimic collagen or support collagen formation, which is essential in both wound healing and tissue regeneration.
In the field of drug development, H-D-trans-Hyp-OMe HCl is used as a component in the design of peptide-based therapeutics targeting diseases related to connective tissue disorders. The compound is incorporated into peptides that mimic collagen's structure or that are involved in the modulation of collagen metabolism. These peptides are being explored for the treatment of conditions such as osteoarthritis, fibrotic diseases, and wound healing disorders. By enhancing collagen synthesis or preventing excessive collagen breakdown, therapies based on H-D-trans-Hyp-OMe HCl may offer novel approaches to treating these challenging conditions.
H-D-trans-Hyp-OMe HCl is also utilized in the synthesis of biomaterials for tissue engineering. Hydroxyproline, as a key amino acid in collagen, is integral to creating scaffolds that promote cell adhesion, tissue regeneration, and the repair of damaged tissues. By incorporating H-D-trans-Hyp-OMe HCl into collagen-like peptides or copolymers, researchers can design materials that mimic the extracellular matrix, offering a more biocompatible environment for tissue growth. This application is particularly valuable in regenerative medicine, where the goal is to restore or replace damaged tissues such as skin, cartilage, or bone.
Another critical application of H-D-trans-Hyp-OMe HCl is in the study of collagen synthesis and folding. The compound is used in research focused on understanding the role of hydroxyproline in collagen stability and the formation of its triple helix structure. It has been shown that modifications to hydroxyproline residues can affect collagen folding, stability, and cross-linking. By incorporating H-D-trans-Hyp-OMe HCl into model peptides, researchers can better understand the biochemical processes that govern collagen's structural integrity, with implications for understanding various collagen-related diseases such as scurvy, osteogenesis imperfecta, and fibrosis.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
