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BS3 Crosslinker disodium is a well-known non-cleavable linker in antibody drug development. Furthermore, it acts as an important promoter of protein-protein interactions through complex cross-linking processes. This compound is widely used in research and diagnostics and shows great potential in exploring drug-target interactions and revealing disease mechanisms.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01534 | -- | $-- |
BS3 Crosslinker disodium, a homobifunctional crosslinker prevalent in protein chemistry and molecular biology research, showcases a myriad of applications. Here are four key applications intricately:
Protein-Protein Interaction Studies: Delving into the realm of protein-protein interactions, BS3 Crosslinker disodium emerges as a pivotal tool. By covalently linking proteins in close proximity, researchers can capture dynamic or enduring interactions under physiological circumstances. This methodology aids in delineating interaction networks and unraveling the intricacies of protein complex formation across diverse biological processes.
Structural Biology: Within the intricate landscape of structural biology, BS3 Crosslinker disodium serves as an indispensable agent for stabilizing protein complexes in structural explorations encompassing techniques like X-ray crystallography and cryo-electron microscopy. By crosslinking proteins prior to analysis or imaging, their native conformations are preserved, offering profound insights into their structural arrangement. This advancement facilitates the elucidation of three-dimensional protein structures, enhancing our understanding of protein assemblies.
Protein Labeling: Venturing into the domain of protein labeling, BS3 Crosslinker disodium plays a pivotal role in attaching various tags or probes to proteins. Reacting with primary amines on the target protein, this crosslinker allows for the attachment of labels such as fluorescent dyes or biotin. This modification enables the detection, quantification, and tracking of proteins across diverse experimental setups, facilitating a deeper understanding of protein dynamics.
Drug Discovery: In the realm of drug discovery, BS3 Crosslinker disodium emerges as a valuable asset for identifying and characterizing potential drug targets. By crosslinking target proteins with small-molecule inhibitors or prospective drug candidates, researchers can unveil crucial insights into binding sites and mechanisms of action. This knowledge plays a pivotal role in optimizing drug design and enhancing therapeutic efficacy, offering promising avenues for advancements in pharmaceutical research.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
