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Acetylene-linker-Val-Cit-PABC-MMAE consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE), Acetylene-linker-Val-Cit-PABC-MMAE is an antibody drug conjugate.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00849 | -- | $-- |
Acetylene-linker-Val-Cit-PABC-MMAE, a crucial chemical linker in antibody-drug conjugates (ADCs) for precise cancer therapy, boasts a multitude of applications. Here are four key applications intricately presented with high perplexity and burstiness:
Targeted Cancer Therapy: Engineered with meticulous precision, Acetylene-linker-Val-Cit-PABC-MMAE facilitates the exclusive delivery of cytotoxic agents to malignant cells by conjugating the linker to an antibody that targets tumor-specific antigens. Once bound to the cancer cell, the linker undergoes cleavage, releasing the potent tubulin inhibitor MMAE and triggering cellular demise. This targeted approach minimizes damage to healthy tissues, reducing side effects compared to conventional chemotherapy protocols.
Pharmaceutical Development: In the realm of drug development, this linker plays a pivotal role in refining the efficacy and safety profiles of novel ADCs through preclinical and clinical investigations. Researchers have the flexibility to customize the linker and payload to optimize stability, release kinetics, and therapeutic efficacy. This iterative process is essential for advancing the next generation of ADCs with heightened clinical effectiveness.
Diagnostic Tool Development: Acetylene-linker-Val-Cit-PABC-MMAE is instrumental in crafting diagnostic imaging agents that illuminate the distribution dynamics of compounds in vivo. By attaching imaging tracers to the linker, scientists can track the localization and accumulation of the conjugate within living organisms, aiding in the evaluation of tumor targeting and ADC biodistribution. This elucidation provides invaluable insights for refining therapeutic approaches.
Biomedical Research: Beyond clinical applications, this linker serves as a versatile tool for exploring drug delivery mechanisms and release kinetics in cellular environments. By unraveling the intricate behavior of the linker across diverse biological contexts, researchers can pioneer innovative strategies for designing more effective and selective therapeutic agents. Furthermore, it aids in elucidating the complexities of tumor biology and identifying novel therapeutic targets in oncology research.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
