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Fmoc-Val-Cit-PAB-MMAE is an antibody drug conjugate contained Fmoc-Val-Cit-PAB and MMAE and probably have antineoplastic activity.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00019 | -- | $-- | Inquiry |
Fmoc-VC-PAB-MMAE is a conjugate used in targeted cancer therapy, particularly in the development of antibody-drug conjugates (ADCs). Here are some key applications of Fmoc-VC-PAB-MMAE:
Targeted Drug Delivery: Fmoc-VC-PAB-MMAE is utilized to create antibody-drug conjugates (ADCs) that deliver cytotoxic drugs selectively to cancer cells. By attaching this conjugate to a monoclonal antibody, the drug can be directed to tumor cells expressing specific antigens. This targeted approach minimizes damage to healthy tissues and enhances the therapeutic index of the drug.
Cancer Treatment: This conjugate has shown promising results in cancer therapy by being an effective payload in ADCs for killing cancer cells. It combines targeted delivery with the potent cytotoxic effect of MMAE, improving the efficacy of cancer treatment. Clinical trials have demonstrated its potential in treating various types of cancers, including lymphoma and breast cancer.
Research and Development: Fmoc-VC-PAB-MMAE is valuable in the preclinical development of new therapeutic agents. Researchers use this conjugate to explore different linker and payload combinations for ADCs. This enables the optimization of ADC stability, efficacy, and safety profiles before advancing to clinical studies.
Pharmacokinetics and Biodistribution Studies: The conjugate is utilized in pharmacokinetic and biodistribution studies to understand how the drug is distributed, metabolized, and eliminated in the body. By studying its behavior in vivo, researchers can optimize the dosing regimens and reduce potential toxicity. This information is crucial for the successful clinical translation of new ADC therapies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
