Boc-D-trans-Hyp-Ome - CAS 135042-17-0

Boc-D-trans-Hyp-Ome - CAS 135042-17-0 Catalog number: BADC-01944

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Boc-D-trans-Hyp-Ome is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.

Category
ADCs Linker
Product Name
Boc-D-trans-Hyp-Ome
CAS
135042-17-0
Catalog Number
BADC-01944
Molecular Formula
C11H19NO5
Molecular Weight
245.27
Boc-D-trans-Hyp-Ome

Ordering Information

Catalog Number Size Price Quantity
BADC-01944 -- $--
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Description
Boc-D-trans-Hyp-Ome is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
Synonyms
(2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate; 1-tert-butyl 2-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate; N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
IUPAC Name
1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate
Canonical SMILES
CC(C)(C)OC(=O)N1CC(CC1C(=O)OC)O
InChI
InChI=1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8+/m0/s1
InChIKey
MZMNEDXVUJLQAF-JGVFFNPUSA-N
Density
1.216±0.06 g/cm3
Purity
98%
Storage
Store at 2-8°C
Boiling Point
335.2±42.0 °C(Predicted)

Boc-D-trans-Hyp-Ome, also identified as Boc-D-trans-4-hydroxyproline methyl ester, plays a pivotal role as a fundamental building block in peptide synthesis. Below are four key applications of Boc-D-trans-Hyp-Ome presented with a high degree of perplexity and burstiness:

Peptide Synthesis: Embraced in the creation of intricate peptides and proteins, Boc-D-trans-Hyp-Ome emerges as a cornerstone. Its integration into peptide structures elevates the stability and structural robustness of the resultant molecules. This attribute proves invaluable in the production of pharmaceutical peptides, endowed with heightened pharmacokinetic properties, fostering the development of therapeutics with enhanced efficacy.

Drug Discovery: Pivotal in drug discovery endeavors, Boc-D-trans-Hyp-Ome finds utility in crafting innovative drug candidates. By incorporating this compound into peptidomimetic configurations, researchers forge compounds characterized by heightened specificity and potency. This strategic utilization expedites the drug discovery process, culminating in the emergence of novel treatments for a myriad of ailments, thereby reshaping the landscape of pharmaceutical innovation.

Protein Engineering: In the realm of protein engineering, Boc-D-trans-Hyp-Ome serves as a linchpin for exploring protein-protein interactions and folding mechanisms. By infusing this building block into protein sequences, scientists unravel the pivotal role of hydroxyproline in fortifying protein structures. This knowledge is instrumental in sculpting proteins equipped with augmented stability and functionality, navigating new frontiers in the realm of biomolecular design.

Biomaterials: Envisioned as a catalyst in biomaterial development for tissue engineering and regenerative medicine, Boc-D-trans-Hyp-Ome distinguishes itself as a key player. The integration of hydroxyproline residues into scaffold materials enhances mechanical properties and biocompatibility. This transformative process ushers in the creation of durable and efficacious materials tailored for medical applications.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Gly-Gly-Phe-OH | Boc-D-trans-Hyp-Ome
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