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α-Amanitin is produced by the strain of Amanita phalloides. It is highly toxic to humans and can cause salivation, vomiting, bleeding, diarrhea, cyanosis, muscle convulsions, spasms, and death. It is the principal toxin of several deadly poisonous mushrooms and exerts its toxic effects by inhibiting RNA polymerase II.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00724 | -- | $-- | Inquiry |
Alpha-Amanitin, a potent toxin derived from select mushrooms, notably the Amanita species, possesses diverse applications. Here are four key uses of Alpha-Amanitin, expressed with high perplexity and burstiness:
Cancer Research: Employed in cancer studies, Alpha-Amanitin targets RNA polymerase II, a pivotal enzyme in mRNA synthesis within eukaryotic cells. By halting this critical process, Alpha-Amanitin disrupts cell transcription, offering insights into cancer cell biology and therapeutic possibilities. Researchers leverage its potent inhibitory nature to unravel mechanisms of tumor cell survival and pinpoint novel drug targets amidst the intricate realm of oncology research.
Toxinology: Serving as a cornerstone in toxinology investigations, Alpha-Amanitin sheds light on the toxic effects and mechanisms of mushroom-induced poisonings. Thorough scrutiny of its impact on human physiology aids in the development of diagnostic tools and treatment strategies for cases of mushroom poisoning. The knowledge garnered from these explorations plays a vital role in enhancing public health responses to incidents of mushroom-related toxicities, ensuring proactive intervention and management.
Molecular Biology: Functioning as a valuable research tool, Alpha-Amanitin selectively blocks RNA polymerase II, enabling the study of gene transcription processes. By precisely impeding mRNA synthesis, researchers dissect the functions of diverse genes and regulatory components, contributing to a deeper comprehension of gene expression dynamics, RNA processing intricacies, and various cellular functions. This nuanced exploration is pivotal in expanding our understanding of the intricate molecular mechanisms governing life.
Pharmaceutical Development: Within the realm of therapeutic agent discovery, Alpha-Amanitin offers a template for investigating enzyme inhibitors that modulate gene expression. While its inherent toxicity poses a challenge, researchers are exploring modified derivatives of Alpha-Amanitin with reduced adverse effects for potential therapeutic applications. This innovative research endeavors to harness the potent inhibitory effects of Alpha-Amanitin while mitigating potential drawbacks, paving the way for novel therapeutic interventions grounded in molecular pharmacology.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
