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Azido palmitic acid is a versatile chemical compound with numerous applications in biological research and bioconjugation. Here are some key applications of azido palmitic acid:
Metabolic Labeling: Azido palmitic acid is used in metabolic labeling to incorporate azide groups into biomolecules such as proteins and lipids. These azide-modified molecules can then be tagged with fluorescent dyes or other probes using click chemistry, allowing researchers to track their dynamics in living cells. This application is invaluable for studying protein localization, trafficking, and interactions within cellular environments.
Protein Lipidation Studies: Azido palmitic acid serves as a probe for investigating protein lipidation, specifically S-palmitoylation. By incorporating this azido fatty acid into cellular proteins, researchers can identify and characterize palmitoylated proteins through subsequent bioorthogonal ligation reactions. This helps in understanding the functional roles of lipid modifications in signal transduction, membrane association, and protein stability.
Bioorthogonal Chemistry: Due to its azide functional group, azido palmitic acid is an essential tool in bioorthogonal chemistry, facilitating the selective modification of biomolecules in complex biological systems. It allows for specific conjugation reactions without interfering with native biochemical processes. This selective reactivity is used in a wide range of applications, including the development of diagnostic assays and targeted drug delivery systems.
Cell Membrane Studies: Azido palmitic acid can be utilized to label and study cell membrane components, providing insights into lipid-protein interactions and membrane dynamics. By incorporating azido-functionalized lipids into cellular membranes, researchers can visualize and analyze membrane organization and properties using fluorescence microscopy. This approach is crucial for exploring membrane-associated processes such as endocytosis, signal transduction, and cell-cell communication.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
