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Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01914 | -- | $-- |
Boc-azetidine-3-carboxylic acid, a chemical compound pivotal in organic synthesis and medicinal chemistry, boasts a spectrum of applications. Here are four key applications presented with high perplexity and burstiness:
Peptide Synthesis: Acting as a fundamental building block in peptide and peptidomimetic synthesis, Boc-azetidine-3-carboxylic acid infuses rigidity and conformational constraints into peptide chains, elevating binding affinity and selectivity for target proteins. This unique attribute underpins the creation of innovative therapeutic peptides endowed with heightened stability and efficacy.
Drug Design and Development: Within the realm of medicinal chemistry, Boc-azetidine-3-carboxylic acid spearheads the design and synthesis of novel drug candidates. By integrating this compound into drug molecules, researchers can fine-tune their pharmacokinetic and pharmacodynamic properties, fostering the emergence of drugs with enhanced bioavailability, diminished side effects, and enriched therapeutic profiles.
Organic Synthesis: As a versatile intermediary in the synthesis of complex organic molecules, Boc-azetidine-3-carboxylic acid shines in generating chiral building blocks for asymmetric synthesis—an indispensable technique for crafting enantiopure compounds. This capability holds particular significance in pharmaceutical, agrochemical, and fine chemical synthesis, where stereochemistry governs activity and efficacy, propelling scientific advancements at the molecular level.
Bioconjugation: Embracing bioconjugation strategies, Boc-azetidine-3-carboxylic acid plays a pivotal role in tethering bioactive molecules to carriers or functional groups, amplifying the delivery and targeting precision of therapeutic agents like drugs and imaging probes. This strategic application serves to optimize therapeutic indices and diagnostic accuracy in biomedical contexts, accentuating the potential for innovative biomedical technologies and precision medicine approaches.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
