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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00948 | -- | $-- | Inquiry |
DBCO-C6-acid, or DibenzoCycloOctyne-C6-acid, is a chemical compound widely recognized for its utility in bioorthogonal chemistry, a field of chemistry that enables highly specific reactions within living systems without interfering with native biochemical processes. This compound features a strained cyclooctyne structure which facilitates rapid and catalyst-free ligation with azides due to its high ring strain and electronic properties. The “C6-acid” component refers to the six-carbon linker appended with a carboxylic acid functional group, providing the compound with enhanced solubility and the ability to conjugate with various biomolecules. The high reactivity and specificity of DBCO-C6-acid make it an invaluable tool for bioconjugation techniques used extensively in molecular biology and drug development.
One of the pivotal applications of DBCO-C6-acid in drug discovery is its role in click chemistry, a technique that allows for the quick and reliable joining of small molecules to functionalize larger compounds, peptides, or proteins. This technique is especially crucial in the early stages of drug development, where researchers need to quickly generate and test large libraries of potential drug candidates. The inherent efficiency of DBCO-C6-acid in forming stable and irreversible bonds with azides means it can be used to “click” therapeutic agents onto targeting ligands with precision, creating conjugates that can better navigate biological environments or deliver drugs more selectively to diseased cells. This capability greatly enhances the drug design process by improving targeting specificity and reducing off-target effects.
Furthermore, DBCO-C6-acid is integral to the advancement of antibody-drug conjugates (ADCs), a class of targeted cancer therapies. In ADCs, a potent cytotoxic drug is linked to an antibody that specifically targets cancer cells, delivering the drug directly to the tumor site while minimizing damage to healthy tissue. The reliable bioorthogonal reactions facilitated by DBCO-C6-acid enable the efficient and site-specific attachment of drugs to antibodies, ensuring maximum therapeutic efficacy. The increased stability and reduced toxicity associated with these conjugates underscore the significance of DBCO-C6-acid in creating next-generation therapeutics that offer improved patient outcomes in oncology.
DBCO-C6-acid also finds significant application in the realm of imaging and diagnostics within drug discovery. By enabling the attachment of imaging agents to biological molecules, it facilitates the visualization and tracking of molecular processes in real time. This is invaluable for understanding disease mechanisms and assessing the pharmacokinetics and biodistribution of new drugs. The precise and robust linking capabilities of DBCO-C6-acid enhance the resolution and reliability of imaging studies, providing detailed insights into drug behavior and interaction within the body. Such contributions are critical for developing more effective diagnostics and for the preclinical evaluation of drug candidates.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
