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DBCO-PEG8-VA-PAB-SG3199 is a drug-linker conjugate for ADC by using SG3199 (a PBD dimer,has a potently cytotoxic against cancer cell lines), linked via DBCO-PEG8-VA-PAB.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00766 | -- | $-- | Inquiry |
DBCO-PEG8-VA-PAB-SG3199, a versatile reagent widely applied in bioconjugation and biomedical research, boasts numerous key applications showcased with high perplexity and burstiness:
Targeted Drug Delivery: Pioneering targeted drug delivery systems, researchers harness DBCO-PEG8-VA-PAB-SG3199 to precisely deliver drug molecules to specific cells or tissues. This tailored approach optimizes therapeutic efficacy and minimizes off-target effects, particularly impactful in the realm of cancer therapy, where enhanced treatment outcomes are paramount.
Biomolecular Labeling: Within biochemical investigations, DBCO-PEG8-VA-PAB-SG3199 shines as a beacon for biomolecular labeling through bioorthogonal chemistry. Its DBCO group enables copper-free click chemistry with azide-containing compounds, facilitating efficient and selective labeling of proteins, nucleic acids, and other biomolecules. This capability empowers tracking and studying molecular behavior within intricate biological systems.
Protein Crosslinking: Unveiling the realm of protein-protein interactions, DBCO-PEG8-VA-PAB-SG3199 serves as a potent crosslinking agent. By forging covalent bonds between proteins, researchers stabilize transient complexes and delve into their structural and functional intricacies. This technique proves invaluable in unraveling signaling pathways and dissecting the molecular underpinnings of protein interactions.
Therapeutic Antibody Development: In the dynamic realm of antibody-drug conjugates (ADCs), DBCO-PEG8-VA-PAB-SG3199 emerges as a linchpin, bridging therapeutic antibodies with cytotoxic agents. The PEG8 spacer heightens the solubility and stability of the conjugates, while the DBCO group streamlines conjugation with azide-functionalized drugs. This integrated strategy elevates the delivery and efficacy of ADCs, offering promising avenues for combatting diverse cancers.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
