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Azido-PEG4-Glu-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01349 | -- | $-- | Inquiry |
Azido-PEG4-Glu-Val-Cit-PAB-MMAE is a chemical conjugate used extensively in targeted cancer therapies. Here are some key applications of Azido-PEG4-Glu-Val-Cit-PAB-MMAE:
Antibody-Drug Conjugates (ADCs): Azido-PEG4-Glu-Val-Cit-PAB-MMAE is a critical linker-payload component in the development of ADCs. These conjugates consist of monoclonal antibodies specific to cancer cell antigens, linked to cytotoxic drugs via the Azido-PEG4-Glu-Val-Cit-PAB-MMAE linker. Upon binding to the cancer cell, the ADC is internalized and the cytotoxic drug is released, killing the cell while sparing healthy tissues.
Directed Drug Delivery: This conjugate is engineered for targeted drug delivery, enhancing the selective toxicity of chemotherapeutic agents. The PEGylation ensures increased solubility and stability, while the Val-Cit dipeptide ensures the payload is released specifically in the presence of tumor-specific proteases. This strategy minimizes systemic side effects and improves therapeutic efficacy.
Cell Imaging and Tracking: Azido-PEG4-Glu-Val-Cit-PAB-MMAE can be utilized in advanced cell imaging techniques. By tagging specific cells with this conjugate, researchers can track and image the distribution and proliferation of these cells in real-time. This application is critical for understanding tumor dynamics and the pharmacokinetics of therapeutic interventions.
Pharmacokinetic Studies: Researchers use Azido-PEG4-Glu-Val-Cit-PAB-MMAE in pharmacokinetic and biodistribution studies to assess the behavior of new drug candidates in the body. By conjugating drugs to this linker-payload, scientists can study how drugs are absorbed, distributed, metabolized, and excreted. These insights are vital for optimizing dosage regimens and improving drug safety profiles.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
