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DM1-(PEG)4-DBCO is a drug conjugate (ADC) consisting of the tubulin inhibitor DM1 and the linker DBCO-PEG4-Ahx. Mertansin (DM1), a tubulin inhibitor, is an antibody-conjugated maytansine developed to overcome the systemic toxicity associated with maytansine and enhance tumor-specific delivery.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01468 | -- | $-- | Inquiry |
DM1-PEG4-DBCO, a versatile chemical compound, acts as a crucial linker for conjugating drugs, particularly in targeted drug delivery systems. Explore its diverse applications:
Antibody-Drug Conjugates (ADCs): DM1-PEG4-DBCO plays a pivotal role in ADC synthesis, serving as a bridge between a therapeutic antibody and a potent cytotoxic drug. This unique function enables precise delivery of the drug directly to cancer cells, minimizing off-target effects and amplifying therapeutic efficacy. The linker ensures stability and controlled release of the drug, optimizing the overall performance of ADCs with finesse.
Bioconjugation: In the realm of research and development, DM1-PEG4-DBCO streamlines the bioconjugation process, allowing the attachment of bioactive molecules to biomolecules like proteins or peptides. This versatility is particularly valuable in crafting probes for cutting-edge imaging and diagnostic applications. The click chemistry mechanism involving DM1-PEG4-DBCO offers a rapid and efficient conjugation process under mild conditions, showcasing its efficiency and effectiveness.
Targeted Cancer Therapy: Pioneering targeted cancer therapy, DM1-PEG4-DBCO is harnessed to deliver cytotoxic agents exclusively to tumor cells. By linking a drug to a targeting moiety, such as a ligand or antibody that binds to cancer cell-specific markers, it heightens the selectivity and potency of the treatment. This targeted precision not only diminishes harmful side effects but also enhances patient outcomes.
Drug Delivery Systems: Embracing sophisticated drug delivery systems, DM1-PEG4-DBCO emerges as a game-changer in designing liposomes or nanoparticles. The PEG4 spacer enhances solubility and flexibility, while the DBCO moiety enables selective conjugation. These meticulously crafted systems ensure that therapeutic agents reach their intended site of action with precision, thereby optimizing pharmacokinetics and enhancing drug biodistribution to elevate the efficacy of treatments.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
