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DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). .
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00020 | 25 mg | $519 | Inquiry |
DM1-SMe, a potent cytotoxic agent, is instrumental in the development of antibody-drug conjugates (ADCs) and cancer research. Here are four key applications of DM1-SMe:
Antibody-Drug Conjugates (ADCs): Serving as the cytotoxic warhead in ADCs for targeted cancer therapy, DM1-SMe is a cornerstone of innovation. By conjugating DM1-SMe to specific antibodies, researchers can precisely deliver the drug to cancer cells while safeguarding healthy tissues. This targeted approach heightens the effectiveness of cancer treatments while mitigating systemic toxicity.
Cancer Cell Line Studies: In the realm of preclinical research, DM1-SMe stands as a powerhouse tool for examining the impact of potent cytotoxic agents on cancer cell lines. Researchers expose diverse cancer cell cultures to DM1-SMe to elucidate its anti-proliferative properties and unravel the mechanisms of cell death.
Drug Resistance Studies: Unveiling the intricate web of drug resistance mechanisms in cancer cells, DM1-SMe emerges as a crucial investigative tool. Through the exposure of resistant cancer cell lines to DM1-SMe, scientists delve into the genetic and biochemical pathways underlying resistance. This in-depth insight serves as a foundation for crafting novel strategies to surmount resistance hurdles and elevate the efficacy of cancer therapies, driving innovation in cancer treatment paradigms.
Pharmacokinetic and Toxicology Studies: Embarking on a journey through pharmacokinetic and toxicology landscapes, DM1-SMe takes center stage in unraveling its behavior within biological systems. Researchers meticulously analyze the distribution, metabolism, and excretion patterns of DM1-SMe in animal models to delineate its safety profile. These studies yield pivotal data essential for designing safer and more efficacious chemotherapy regimens, forging a path towards enhanced patient outcomes and improved treatment protocols.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
