DUPA(OtBu)-OH is a PEG linker for antibody-drug-conjugation (ADC). DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
DUPA(OtBu)-OH, also known as 23-dehydro-2-deoxy-N-trifluoroacetylneuraminic acid, is a versatile chemical intermediate with a multitude of applications in bioscience. Here are four key applications of DUPA(OtBu)-OH:
Cancer Research: Playing a pivotal role in the realm of cancer research, DUPA(OtBu)-OH is indispensably utilized in the synthesis of targeted therapeutic agents tailored for prostate cancer. By binding to specific ligands, it facilitates the development of compounds capable of selectively attaching to cancer cells expressing the Prostate-Specific Membrane Antigen (PSMA). This targeted strategy not only enhances the effectiveness of cancer treatments but also diminishes the adverse effects associated with traditional therapies.
Drug Delivery Systems: Embracing the potential of DUPA(OtBu)-OH, researchers are harnessing its properties in the creation of drug conjugates designed to revolutionize drug delivery systems. Through precise binding to receptors on target cells, it ensures the accurate delivery of therapeutics to specific tissues, thereby amplifying treatment efficiency. This innovative method plays a crucial role in minimizing systemic toxicity while enhancing therapeutic outcomes, marking a significant advancement in the field of drug delivery.
Molecular Imaging: At the forefront of molecular imaging, DUPA(OtBu)-OH emerges as a key component in the development of imaging agents for diagnostic purposes. By conjugating with radioactive isotopes or fluorescent markers, it facilitates the visualization of PSMA-expressing tumors using cutting-edge techniques such as Positron Emission Tomography (PET) or fluorescence imaging. This application represents a substantial leap in cancer detection and monitoring, offering heightened precision and accuracy in diagnostic imaging.
Receptor Binding Studies: Serving as an invaluable tool in the exploration of receptor-ligand interactions, DUPA(OtBu)-OH enables researchers to delve into the intricacies of binding affinities and specificities between different ligands and PSMA. By synthesizing analogs of DUPA(OtBu)-OH, scientists can unravel the complex web of molecular interactions crucial for designing more potent therapeutic agents and diagnostics with enhanced efficacy. This comprehensive understanding of receptor binding dynamics propels forward the development of advanced bioactive compounds.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.