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6-Maleimidohexanoic Acid N-Hydroxysuccinimide Ester is used for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01500 | 100 g | $839 |
| NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
|---|---|---|---|---|---|
| NCT03600649 | Ewing Sarcoma | Phase 1 | 2021-09-30 | Salarius Pharmaceuticals, LLC | Recruiting |
| NCT01659203 | 2020-09-03 | Massachusetts General Hospital | Recruiting | ||
| NCT04429412 | Brief Psychotic Disorder | Not Applicable | 2020-06-12 | Fundaci Sant Joan de Du | Completed |
| NCT03652272 | Medication Adherence | Not Applicable | 2021-10-01 | Northwestern University | Recruiting |
| NCT00974155 | Depression | Phase 4 | 2015-04-01 | K. Lieb | Completed |
6-Maleimidohexanoic Acid N-Hydroxysuccinimide Ester, a versatile chemical reagent with multifaceted biochemical applications, assumes a pivotal role across various fields. Here are four key applications presented with a high degree of perplexity and burstiness:
Protein Labeling: Unveiling its potency in protein labeling, this ester facilitates the attachment of fluorescent dyes, biotin, or other probes to proteins. The maleimide group selectively engages with thiol groups on cysteine residues, while the N-hydroxysuccinimide (NHS) ester interacts with primary amines on lysine residues. This dual reactivity permits precise fluorescent tagging and tracking of proteins in an array of biochemical assays and imaging studies, unveiling novel insights into protein behavior and function.
Antibody Conjugation: In the vast realm of immunochemistry, 6-Maleimidohexanoic Acid NHS Ester stands as an indispensable tool for linking antibodies with enzymes, fluorophores, or other functional molecules. This seamless fusion of antibodies with detection molecules amplifies the sensitivity and specificity of assays like ELISA and western blotting, refining the precision of diagnostic tests and research endeavors. The conjugation process serves as the cornerstone for crafting cutting-edge tools to detect and study biological markers.
Surface Modification: Venturing into the intricate realm of surface modification, 6-Maleimidohexanoic Acid NHS Ester showcases its adaptability by enabling the modification of various surfaces such as nanoparticles, beads, and microarray slides. Through the covalent linkage of ligands or recognition elements to these diverse surfaces, researchers can engineer functionalized platforms for biosensing, diagnostics, and analytical applications.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
