(R)-(+) Azetidine-2-carboxylic acid - CAS 7729-30-8

(R)-(+) Azetidine-2-carboxylic acid - CAS 7729-30-8 Catalog number: BADC-01937

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(R)-(+) Azetidine-2-carboxylic acid is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.

Category
ADCs Linker
Product Name
(R)-(+) Azetidine-2-carboxylic acid
CAS
7729-30-8
Catalog Number
BADC-01937
Molecular Formula
C4H7NO2
Molecular Weight
101.10
(R)-(+) Azetidine-2-carboxylic acid

Ordering Information

Catalog Number Size Price Quantity
BADC-01937 -- $--
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Description
(R)-(+) Azetidine-2-carboxylic acid is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
Synonyms
(R)-azetidine-2-carboxylic acid; D-Azetidine-2-carboxylic acid; (2R)-azetidin-1-ium-2-carboxylate
IUPAC Name
(2R)-azetidine-2-carboxylic acid
Canonical SMILES
C1CNC1C(=O)O
InChI
InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m1/s1
InChIKey
IADUEWIQBXOCDZ-GSVOUGTGSA-N
Density
1.275±0.06 g/cm3
Solubility
Soluble in Methanol (Slightly), Methanol (Slightly)
Melting Point
209-211°C
Appearance
White to off-white Solid
Purity
97.0%
Boiling Point
242.0±33.0 °C at 760 mmHg

(R)-(+) Azetidine-2-carboxylic acid, a versatile chiral building block, finds diverse applications in various scientific domains. Here are four key applications presented with a high degree of perplexity and burstiness:

Pharmaceutical Synthesis: As a pivotal chiral intermediate, (R)-(+) Azetidine-2-carboxylic acid plays a crucial role in synthesizing an array of pharmaceutical compounds. Its intricate structure enables the generation of complex molecules essential for drug development, particularly in crafting anti-inflammatory and antiviral agents. The stereochemistry offered by this compound is indispensable in ensuring the desired therapeutic efficacy of the resulting drugs, showcasing the intricate dance of chemistry in medicine.

Peptide and Protein Chemistry: Delving into the realm of peptides and proteins, this compound acts as an unnatural amino acid analog, elevating the stability and biological activity of synthesized molecules. Incorporating (R)-(+) Azetidine-2-carboxylic acid into peptide sequences not only enhances their functionality but also aids researchers in exploring protein folding dynamics and innovating novel biomolecules with enhanced properties, illustrating the fusion of creativity and science in biomolecular design.

Asymmetric Synthesis: Organic chemistry witnesses the invaluable contribution of (R)-(+) Azetidine-2-carboxylic acid as a powerful tool for asymmetric synthesis, enabling the production of enantiomerically pure compounds. Its integration in catalytic reactions facilitates the generation of products with precise chiral configurations, a critical aspect for developing catalysts for industrial sectors and crafting chiral ligands. This synthesis journey exemplifies the meticulous artistry behind creating specific molecular shapes and configurations.

Material Science: Venturing into the realm of advanced materials, (R)-(+) Azetidine-2-carboxylic acid finds application in shaping polymers and hydrogels with unique mechanical and thermal characteristics. Its incorporation into polymer chains unlocks a realm of possibilities for creating materials tailored for specific applications, ranging from drug delivery systems to biodegradable plastics and responsive materials. This synergy of chemistry and material science heralds a new era of innovation in material engineering, blending creativity with functionality for diverse applications.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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