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| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00434 | -- | $-- |
5-Hexynoic NHS ester, a versatile chemical reagent extensively utilized in bioconjugation and chemical biology, offers a multitude of applications. Here are four key applications presented with high perplexity and burstiness:
Protein Labeling: A common practice involves utilizing 5-Hexynoic NHS ester to label proteins with alkyne groups, setting the stage for subsequent ""click"" chemistry reactions with azide-functionalized molecules. These labeled proteins become crucial components in diverse biochemical assays and imaging studies, providing valuable insights into cellular processes at a molecular level.
Antibody Conjugation: The reactive NHS ester group in 5-Hexynoic NHS ester engages with primary amines, making it a prime candidate for conjugating antibodies. This conjugation process yields antibody-drug conjugates tailored for targeted drug delivery or facilitates the labeling of antibodies with fluorescent dyes. These conjugates play a pivotal role in diagnostic and therapeutic applications, enhancing precision in disease detection and treatment.
Surface Functionalization: Enabling surface modification with alkyne groups, 5-Hexynoic NHS ester opens the door to bioorthogonal reactions that drive the development of biosensors and microarrays. These applications find significance in high-throughput screening and diagnostic technologies, offering a glimpse into the intricate interactions between biomolecules on a structured surface.
Chemical Biology Research: Within the realm of chemical biology, 5-Hexynoic NHS ester emerges as a key player in introducing alkyne functionalities into small molecules and peptides, paving the way for click chemistry-based studies of biological interactions. By tagging molecules with alkyne groups, researchers gain insights into cellular pathways and identify potential drug targets, propelling advancements in drug discovery and development.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
