6-Azidohexanoic acid NHS ester - CAS 866363-70-4

6-Azidohexanoic acid NHS ester - CAS 866363-70-4 Catalog number: BADC-00410

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A noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
6-Azidohexanoic acid NHS ester
CAS
866363-70-4
Catalog Number
BADC-00410
Molecular Formula
C10H14N4O4
Molecular Weight
254.24
6-Azidohexanoic acid NHS ester

Ordering Information

Catalog Number Size Price Quantity
BADC-00410 1 g $1099
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Description
A noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
N3-C5-NHS ester
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 6-azidohexanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCCCCN=[N+]=[N-]
InChI
InChI=1S/C10H14N4O4/c11-13-12-7-3-1-2-4-10(17)18-14-8(15)5-6-9(14)16/h1-7H2
InChIKey
FVWGCTQOFSJEDB-UHFFFAOYSA-N
Appearance
Slightly yellow oil
Purity
≥ 95% (HPLC)
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, desiccate and shipped at ambient temperature

6-Azidohexanoic acid NHS ester, a versatile reagent widely utilized in bioconjugation and chemical biology, is a key player in various applications. Here we explore its diverse uses with a twist of high perplexity and burstiness.

Protein Labeling: Enter the realm of protein modification with 6-Azidohexanoic acid NHS ester, the magic wand that covalently links azide groups to proteins through click chemistry. This innovative technique allows for the seamless labeling and monitoring of proteins using fluorescent probes or affinity tags. Witness these conjugated proteins in action, illuminating assays like fluorescence microscopy and Western blotting with their dynamic presence.

Peptide Synthesis: Embark on a journey through peptide synthesis where 6-Azidohexanoic acid NHS ester reigns supreme in incorporating azide functionality into peptides. These azide-modified peptides pave the way for click chemistry reactions, forming peptide conjugates with biomolecules like PEG chains or drugs. Dive into the world of peptide-based therapeutics and delivery systems, where this strategy orchestrates intricate molecular dances for therapeutic advancements.

Nanoparticle Functionalization: Behold the transformative powers of 6-Azidohexanoic acid NHS ester in nanoparticle functionalization, where azide groups bring forth endless possibilities through click chemistry. Witness the evolution of functionalized nanoparticles as they partner with targeting ligands, drugs, or imaging agents. Experience the birth of targeted drug delivery systems and diagnostic imaging tools where precision meets innovation in the realm of healthcare advancements.

Surface Immobilization: Step into the realm of surface engineering with 6-Azidohexanoic acid NHS ester as it paints surfaces with azide groups, like an artist creating a masterpiece. Watch as these azide-functionalized surfaces come to life, ready to host biomolecules through click chemistry, birthing bioactive surfaces for biosensors and cell culture substrates. Explore the realm of advanced biosensors and biointerfaces, where the language of molecular interactions unfolds, shaping the future of diagnostic and research endeavors.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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