Ald-CH2-PEG5-azide - CAS 1446282-38-7

Ald-CH2-PEG5-azide - CAS 1446282-38-7 Catalog number: BADC-00953

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Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Ald-CH2-PEG5-azide
CAS
1446282-38-7
Catalog Number
BADC-00953
Molecular Formula
C12H23N3O6
Molecular Weight
305.33
Ald-CH2-PEG5-azide

Ordering Information

Catalog Number Size Price Quantity
BADC-00953 -- $--
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Description
Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Ald-PEG5-azide; CHO-PEG5-azide; 17-Azido-3,6,9,12,15-pentaozaoctadecanal
IUPAC Name
2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetaldehyde
Canonical SMILES
C(COCCOCCOCCOCCOCC=O)N=[N+]=[N-]
InChI
InChI=1S/C12H23N3O6/c13-15-14-1-3-17-5-7-19-9-11-21-12-10-20-8-6-18-4-2-16/h2H,1,3-12H2
InChIKey
VYTIEPBAXZXQJS-UHFFFAOYSA-N
Solubility
10 mm in DMSO
LogP
-1.49
Purity
≥95%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -5°C,keep in dry and avoid sunlight.

Ald-CH2-PEG5-azide, a versatile bifunctional crosslinker essential in biochemical research and drug development, has diverse applications in various domains. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Positioned as a cornerstone in molecular linking through click chemistry, Ald-CH2-PEG5-azide empowers researchers to forge connections between biomolecules by linking azide-functionalized molecules to aldehyde-containing targets. This intricate process fosters the synthesis of hybrid structures, such as proteins and nucleic acids, pivotal for the advancement of cutting-edge diagnostic tools and therapeutic agents.

Drug Delivery: Within the realm of drug development, Ald-CH2-PEG5-azide assumes a pivotal role in augmenting the solubility, stability, and biocompatibility of drug molecules. Through conjugation with polyethylene glycol (PEG) chains, therapeutic compounds undergo modification to enhance drug delivery efficiency, extending circulation time and enabling targeted delivery. This innovative paradigm yields optimized pharmacokinetic profiles and mitigates off-target effects, heralding a new era in drug delivery precision.

Surface Functionalization: Bridging material science and bioengineering realms, Ald-CH2-PEG5-azide serves as a linchpin in functionalizing nanoparticle surfaces, polymers, and an array of materials. By introducing azide groups onto surfaces, researchers seamlessly integrate a myriad of functional molecules, including targeting ligands and imaging agents. This foundational process underpins the development of cutting-edge materials for biomedical applications, such as biosensors and sophisticated drug delivery systems, propelling the frontier of bioengineering.

Proteomics: Playing a pivotal role in unraveling the intricacies of protein interactions and modifications, Ald-CH2-PEG5-azide facilitates crosslinking experiments that capture fleeting protein-protein interactions and delineate protein networks within cells.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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