Biotin-PEG3-Me-Tet - CAS 2143968-06-1

Biotin-PEG3-Me-Tet - CAS 2143968-06-1 Catalog number: BADC-01810

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Biotin-PEG3-Me-Tet is an ADC linker containing 3 PEG units.

Category
ADCs Linker
Product Name
Biotin-PEG3-Me-Tet
CAS
2143968-06-1
Catalog Number
BADC-01810
Molecular Formula
C29H42N8O6S
Molecular Weight
630.76

Ordering Information

Catalog Number Size Price Quantity
BADC-01810 -- $--
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Description
Biotin-PEG3-Me-Tet is an ADC linker containing 3 PEG units.
Synonyms
N-(1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenyl)-3-oxo-6,9,12-trioxa-2-azatetradecan-14-yl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
IUPAC Name
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]pentanamide
Canonical SMILES
CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCNC(=O)CCCCC3C4C(CS3)NC(=O)N4
InChI
InChI=1S/C29H42N8O6S/c1-20-34-36-28(37-35-20)22-8-6-21(7-9-22)18-31-26(39)10-12-41-14-16-43-17-15-42-13-11-30-25(38)5-3-2-4-24-27-23(19-44-24)32-29(40)33-27/h6-9,23-24,27H,2-5,10-19H2,1H3,(H,30,38)(H,31,39)(H2,32,33,40)/t23-,24-,27-/m0/s1
InChIKey
CJVUSGLIHMFDML-DPZBCOQUSA-N
Density
1.238±0.06 g/cm3

Biotin-PEG3-Me-Tet is a versatile reagent used in various biochemical and cell biology applications. Here are some key applications of Biotin-PEG3-Me-Tet:

Protein Labeling: Biotin-PEG3-Me-Tet is widely used for labeling proteins to facilitate their detection and purification. The biotin moiety binds strongly to streptavidin, allowing for efficient capture and analysis of biotinylated proteins. This is particularly useful in Western blotting, ELISA, and immunoprecipitation techniques.

Cell Surface Engineering: This reagent can modify cell surfaces by biotinylating membrane proteins, enabling their study and manipulation. The PEG linker ensures minimal steric hindrance and preserves the functionality of proteins. This application is critical for cell sorting, imaging, and the creation of cell-based assays.

Drug Delivery Systems: Biotin-PEG3-Me-Tet is employed in designing targeted drug delivery systems. By conjugating therapeutic agents to biotin, they can be directed to specific cells or tissues expressing streptavidin or avidin. This targeting improves the efficacy and reduces the side effects of the delivered therapeutics.

Biosensor Development: The unique properties of Biotin-PEG3-Me-Tet make it an excellent candidate for developing biosensors. These biosensors leverage the high affinity interaction between biotin and streptavidin to detect various biomolecules. This application is crucial in diagnostic assays and environmental monitoring systems.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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