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Boc-GGFG-PAB-OH is a biomedical chemical product with a variety of potential applications. As a promising small molecule reagent, it is widely used in the field of bioconjugation, especially antibody-drug conjugation.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01439 | -- | $-- | Inquiry |
Boc-GGFG-PAB-OH, a versatile peptide linker, plays a pivotal role in the synthesis of sophisticated drug delivery systems like antibody-drug conjugates (ADCs). Here are four key applications presented with high perplexity and burstiness:
Antibody-Drug Conjugates (ADCs): Serving as a cleavable linker in ADC synthesis, Boc-GGFG-PAB-OH intricately binds a cytotoxic drug to an antibody. This linker is meticulously designed to remain stable in circulation while undergoing cleavage upon internalization into target cells, ensuring precise drug release at the therapeutic site. This targeted mechanism mitigates off-target effects and boosts therapeutic efficacy significantly.
Prodrug Development: Pioneering prodrug strategies, Boc-GGFG-PAB-OH facilitates the creation of compounds that activate selectively in specific microenvironments such as the acidic milieu of tumor tissues. This peptide linker guarantees that the active drug is liberated only under predetermined conditions, minimizing systemic toxicity effectively. The strategic activation enhances the safety profile of chemotherapeutic agents, marking a breakthrough in tailored drug delivery approaches.
Controlled Drug Release Systems: Seamlessly integrating into controlled drug release systems, Boc-GGFG-PAB-OH enables the engineering of drugs for gradual release over defined durations or in response to precise physiological cues. By leveraging this linker, drugs can be tailor-made to maintain therapeutic levels steadily, enhancing patient compliance significantly.
Cellular Assays and Research: A cornerstone of intracellular drug delivery studies, Boc-GGFG-PAB-OH is a valuable asset in investigating drug mechanisms and linker stability within cells. Researchers leverage this linker to synthesize conjugates and assess how different linkers influence drug release dynamics and cellular uptake. These in-depth analyses are instrumental in refining drug delivery system designs and elevating their clinical impact exponentially.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
