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Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01132 | -- | $-- |
Bromo-PEG2-azide, a versatile chemical linker pivotal in bio-conjugation, click chemistry, and surface modification, boasts a myriad of applications. Here are four key applications:
Bio-Conjugation: This invaluable reagent links biomolecules such as proteins, peptides, and nucleic acids using its azide and bromo functional groups. The flexible PEG spacer mitigates steric hindrance, enhancing the stability and activity of the conjugates. This unique capability allows for the assembly of intricate biomolecular structures, pivotal in diagnostic assays and therapeutic interventions.
Click Chemistry: At the core of click chemistry reactions, Bromo-PEG2-azide plays a critical role in azide-alkyne cycloaddition. Through interaction with alkyne-containing molecules, it forms stable triazole linkages widely utilized in chemical biology and materials science. This process facilitates the creation of well-defined macromolecular structures and functionalized surfaces, crucial for drug discovery and nanoengineering pursuits.
Surface Modification: Facilitating the functionalization of diverse surfaces like nanoparticles, polymers, and biosensors, Bromo-PEG2-azide stands as a versatile tool. By attaching this compound to surfaces, researchers can introduce reactive azide groups for subsequent bioconjugation or biomolecule immobilization. This technique enhances the biocompatibility and functionality of surfaces, elevating their performance in biomedical devices and analytical assays.
Drug Delivery Systems: In the domain of advanced drug delivery systems, Bromo-PEG2-azide assumes a pivotal role. Its functional groups enable the attachment of therapeutic agents to delivery platforms like nanoparticles or hydrogels through bio-orthogonal reactions. This facilitates controlled and targeted drug delivery, enhancing efficacy and minimizing side effects in clinical treatments.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
