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Br-PEG4-COOtBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01136 | -- | $-- | Inquiry |
Br-PEG4-COOtBu, also recognized as tert-butyl 4-(2-bromoethyl)phenyl ether, stands as a versatile reagent commonly applied in chemical and biochemical studies. Here are four key applications of Br-PEG4-COOtBu:
Protein Modification: A staple in protein modification, Br-PEG4-COOtBu finds frequent use in enhancing the solubility and stability of proteins. By conjugating the PEG4 moiety to proteins, researchers can mitigate protein aggregation and prolong protein longevity. This process plays a pivotal role in optimizing the effectiveness of therapeutic proteins and enzymes across diverse applications.
Drug Delivery: Within drug delivery methodologies, Br-PEG4-COOtBu serves as a crucial component in linking drugs to polymers or nanoparticles. The PEGylation process enhances drug pharmacokinetics and distribution, ultimately improving therapeutic efficacy. This tailored approach proves particularly advantageous in targeting specific tissues and minimizing immunogenic responses.
Bioconjugation: As a key linker in bioconjugation strategies, Br-PEG4-COOtBu facilitates the attachment of biomolecules like antibodies, peptides, and nucleic acids to various substrates. This capability plays a pivotal role in developing biosensors, diagnostic tools, and targeted therapies. The PEG4 spacer arm adds flexibility and diminishes steric hindrances, elevating the functionality of the resulting conjugates and underscoring the intricate landscape of bioconjugation chemistry.
Surface Modification: In the realm of material science, Br-PEG4-COOtBu is harnessed to tailor the surface characteristics of diverse materials, from polymers to nanoparticles and hydrogels. By integrating this reagent, surfaces can be modified to be more hydrophilic or hydrophobic based on specific application needs. This precision enables the customization of materials for specialized biomedical and industrial uses, revealing the nuanced artistry of material surface engineering.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
