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Br-PEG4-NHBoc is a PEG linker containing a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00940 | -- | $-- |
Br-PEG4-NHBoc, a bifunctional polyethylene glycol (PEG) derivative, is widely used in bioscience and biochemistry applications. Here are some key applications of Br-PEG4-NHBoc:
Drug Delivery Systems: Br-PEG4-NHBoc is employed in the development of advanced drug delivery systems. Its PEGylation properties enhance the solubility and stability of therapeutic molecules, improving their pharmacokinetics and reducing immunogenicity. This enables the creation of long-circulating drug formulations for better therapeutic outcomes.
Bioconjugation: This compound is useful for bioconjugation processes, where it acts as a linker molecule between biomolecules. By facilitating the attachment of peptides, proteins, or small molecules to other entities, Br-PEG4-NHBoc helps in creating multifunctional bioconjugates. These bioconjugates are essential in diagnostic assays, therapeutic applications, and biomaterials science.
Surface Modification: Br-PEG4-NHBoc is used to modify surfaces of nanoparticles, biosensors, and medical devices to improve their biocompatibility. The PEGylation imparts antifouling properties, minimizing non-specific binding and prolonging device longevity. This is particularly important in the development of medical implants and in vivo diagnostic tools.
Protein Engineering: In protein engineering, Br-PEG4-NHBoc is utilized to modify proteins by site-specific PEGylation. This modification can enhance the therapeutic properties of proteins by increasing their stability and half-life. It is widely used in the development of biologic drugs such as enzyme replacement therapies and monoclonal antibodies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
