Fmoc-GGFG-OH - CAS 1817857-75-2

Fmoc-GGFG-OH - CAS 1817857-75-2 Catalog number: BADC-01446

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Fmoc-GGFG-OH is a protease cleavable linker used for the antibody-drug conjugate (ADC).

Category
ADCs Linker
Product Name
Fmoc-GGFG-OH
CAS
1817857-75-2
Catalog Number
BADC-01446
Molecular Formula
C30H30N4O7
Molecular Weight
558.60
Fmoc-GGFG-OH

Ordering Information

Catalog Number Size Price Quantity
BADC-01446 500 mg $228
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Description
Fmoc-GGFG-OH is a protease cleavable linker used for the antibody-drug conjugate (ADC).
Synonyms
Fmoc-Gly-Gly-Phe-Gly-OH; (((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycyl-L-phenylalanylglycine
IUPAC Name
2-[[(2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NCC(=O)O)NC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
InChI
InChI=1S/C30H30N4O7/c35-26(31-16-27(36)34-25(29(39)32-17-28(37)38)14-19-8-2-1-3-9-19)15-33-30(40)41-18-24-22-12-6-4-10-20(22)21-11-5-7-13-23(21)24/h1-13,24-25H,14-18H2,(H,31,35)(H,32,39)(H,33,40)(H,34,36)(H,37,38)/t25-/m0/s1
InChIKey
LCOCGQVZUSLQJD-VWLOTQADSA-N
Appearance
White Solid

Fmoc-GGFG-OH, a fluorine-modified peptide with diverse bioscience applications, is a key player in research and therapeutic advancements. Here are four essential applications of Fmoc-GGFG-OH:

Peptide Synthesis: In the realm of solid-phase peptide synthesis, Fmoc-GGFG-OH shines as a foundational element for constructing complex peptides and proteins. The Fmoc group acts as a safeguard, ensuring the precise assembly of sequences during synthesis. This application is indispensable for crafting tailored peptides for both research purposes and therapeutic applications.

Drug Delivery Systems: Delving into the realm of targeted drug delivery, researchers are exploring the potential of modified peptides like Fmoc-GGFG-OH. By tethering therapeutic compounds to this peptide, novel conjugates are fashioned to transport drugs directly to specific cells or tissues. This strategic approach enhances the efficacy and precision of treatments, particularly in the context of cancer therapy, offering new avenues for more effective and targeted drug administration.

Bioconjugation Studies: Fmoc-GGFG-OH takes center stage in bioconjugation endeavors, serving as a bridge to connect peptides with a myriad of molecules, such as fluorescent dyes or pharmaceuticals. The glycine-glycine-phenylalanine-glycine (GGFG) sequence within this peptide offers both flexibility and stability in the linker region, enabling seamless molecular interactions. This methodology streamlines the detection and monitoring of biological processes, both in controlled laboratory settings and within living organisms.

Protein Engineering: Pioneering protein engineering scientists leverage the unique properties of Fmoc-GGFG-OH to refine and enhance protein functionalities. By integrating this peptide into protein structures, researchers can explore its impact on crucial aspects like folding, stability, and enzymatic activity. This application is pivotal in the quest to develop novel biopharmaceuticals and unravel the intricate mechanisms governing protein behavior.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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