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Cbz-(D-Glu)Bn-Gly-Gly-Gly-Gly is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01888 | -- | $-- | Inquiry |
Cbz-D-Glu(Bn)-Gly-Gly-Gly-Gly, a specialized peptide used in diverse biochemical and pharmaceutical research endeavors, finds applications across various domains. Here are four key applications:
Peptide Synthesis: Serving as a fundamental constituent in peptide synthesis, Cbz-D-Glu(Bn)-Gly-Gly-Gly-Gly acts as a pivotal building block for constructing intricate peptide structures. Its protected form, featuring a benzyloxycarbonyl (Cbz) group, facilitates a stepwise peptide assembly process by preventing premature reactions. This enables the tailored creation of peptides with precise sequences and structures, catering to both research and therapeutic investigations.
Protease Inhibition Studies: In the realm of protease research, this peptide serves as a vital substrate for elucidating the specificity and activity of proteases. Researchers leverage it to measure the cleavage rates by various proteases, shedding light on enzyme kinetics and the efficacy of inhibitors. Such studies are imperative for the development of protease inhibitors, crucial therapeutic agents combating diseases characterized by protease dysregulation.
Drug Design and Discovery: Embracing innovation in drug discovery, Cbz-D-Glu(Bn)-Gly-Gly-Gly-Gly plays a valuable role in screening assays to uncover compounds interacting with specific peptide sequences. Scientists harness these assays to unearth novel drugs or design molecules modulating protein-protein interactions. This approach proves invaluable in tackling diseases with intricate molecular pathways, offering a potential avenue for targeted therapeutic interventions.
Structural Biology: Offering insights into structural biology investigations, including nuclear magnetic resonance (NMR) and X-ray crystallography, Cbz-D-Glu(Bn)-Gly-Gly-Gly-Gly serves as a cornerstone. By incorporating this peptide into larger protein or peptide structures, researchers stabilize and explore three-dimensional molecular configurations. This knowledge is paramount for deciphering protein functionalities, interactions, and rationalizing drug design strategies, exemplifying the intricate interplay within biological systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
