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CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00847 | -- | $-- |
CL2-SN-38, a prodrug yielding the potent topoisomerase I inhibitor SN-38, finds diverse applications. Here are four key uses:
Anticancer Therapy: Utilized in treating various cancers, especially metastatic colorectal cancer, CL2-SN-38 undergoes conversion to SN-38 within the tumor microenvironment. This transformation enables selective targeting of cancer cells while sparing normal tissues, resulting in heightened antitumor efficacy coupled with diminished systemic toxicity.
Targeted Drug Delivery: Through conjugation with antibodies or nanoparticles, CL2-SN-38 achieves precise delivery to specific tumor sites, minimizing off-target effects and elevating the drug’s therapeutic index. Such targeted strategies not only enhance patient outcomes but also mitigate adverse side effects, revolutionizing the landscape of drug delivery systems.
Research Tool: Serving as a pivotal research tool in preclinical studies, CL2-SN-38 aids in deciphering the mechanisms of topoisomerase I inhibitors. Researchers leverage it to investigate drug resistance mechanisms and screen for potential combination therapies, offering critical insights for the advancement of more potent cancer treatments.
Pharmacokinetics Studies: Integral to drug development endeavors, CL2-SN-38 plays a crucial role in elucidating the pharmacokinetics and biodistribution of prodrugs. Through the examination of SN-38 release and activation, researchers can fine-tune dosing regimens and delivery methods, essential for optimizing therapeutic efficacy and minimizing toxicity in clinical settings.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
