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CL2A-SN 38 is a drug-linker conjugate for ADC by using SN 38 (a DNA Topoisomerase I inhibitor), linked via CL2A.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00742 | 5 mg | $319 |
CL2A-SN 38, a potent chemotherapeutic agent derived from the active metabolite of irinotecan SN-38, holds immense significance in cancer treatment and research. Here are four key applications of CL2A-SN 38:
Targeted Cancer Therapy: Utilizing CL2A-SN 38 for targeted chemotherapy, researchers deliver precise treatment to cancer cells while minimizing harm to healthy tissues. Through conjugation with antibodies or nanoparticles that selectively bind to cancer cell markers, drug delivery precision is enhanced. This tailored approach boosts treatment effectiveness and diminishes adverse effects linked to conventional chemotherapy.
Pharmacokinetic Studies: CL2A-SN 38 plays a pivotal role in pharmacokinetic investigations to unravel its absorption, distribution, metabolism, and excretion (ADME) profiles. Researchers leverage these studies to fine-tune dosing schedules and optimize therapeutic outcomes. The insights gathered are essential for crafting safer and more potent chemotherapeutic strategies.
Combination Therapy Research: Researchers frequently explore CL2A-SN 38 in combination with other chemotherapy agents or targeted therapies to assess synergistic effects. These studies aim to uncover combination regimens that heighten anti-tumor activity and overcome resistance mechanisms. Such investigations have the potential to unveil more potent multi-drug cancer treatment approaches.
Cell Line and Animal Model Testing: In preclinical studies involving cancer cell lines and animal models, CL2A-SN 38 is a commonly utilized agent. Researchers evaluate its cytotoxic properties, efficacy, and mechanisms of action across various cancer subtypes. These investigations yield invaluable insights that inform the design of clinical trials and therapeutic strategies in the field of oncology.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
