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DBCO-PEG4-VC-PAB-DMEA-PNU159682 is a drug-linker conjugate for ADC by using PNU159682 (a potent DNA topoisomerase II inhibitor), linked via DBCO-PEG4-VC-PAB-DMEA.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00762 | -- | $-- | Inquiry |
DBCO-PEG4-VC-PAB-DMEA-PNU159682 is a complex bioconjugation reagent often used in drug delivery and molecular targeting applications. Here are some key applications of DBCO-PEG4-VC-PAB-DMEA-PNU159682:
Targeted Drug Delivery: DBCO-PEG4-VC-PAB-DMEA-PNU159682 can be utilized to deliver therapeutic molecules specifically to cancer cells. By conjugating this reagent to an antibody or other targeting moiety, it can bind selectively to tumor-specific markers. This ensures that the attached drug is released primarily at the site of the tumor, minimizing off-target effects and improving therapeutic efficacy.
Prodrug Activation: This reagent is employed in the design of prodrugs, which are inactive precursors of drugs that become activated in the body. The linkage in DBCO-PEG4-VC-PAB-DMEA-PNU159682 can be cleaved in the tumor microenvironment, releasing the active drug PNU159682. This strategy enhances the drug’s concentration at the desired site while reducing systemic toxicity.
Bioconjugation Research: DBCO-PEG4-VC-PAB-DMEA-PNU159682 is a valuable tool in bioconjugation studies. It allows for the attachment of various biomolecules, such as peptides, proteins, and nucleic acids, through click chemistry reactions. This facilitates the exploration of new therapeutic constructs and diagnostic agents with precise molecular architecture.
Therapeutic Antibody Development: In the field of therapeutic antibody development, DBCO-PEG4-VC-PAB-DMEA-PNU159682 is vital for creating antibody-drug conjugates (ADCs). These conjugates combine the targeting ability of antibodies with the potency of cytotoxic drugs. By ensuring a stable and specific linkage, this reagent helps in generating ADCs that can target and kill cancer cells effectively.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
