Disuccinimidyl glutarate - CAS 79642-50-5

Disuccinimidyl glutarate - CAS 79642-50-5 Catalog number: BADC-01162

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DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins.

Category
ADCs Linker
Product Name
Disuccinimidyl glutarate
CAS
79642-50-5
Catalog Number
BADC-01162
Molecular Formula
C13H14N2O8
Molecular Weight
326.26
Disuccinimidyl glutarate

Ordering Information

Catalog Number Size Price Quantity
BADC-01162 -- $--
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Description
DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins.
Synonyms
DSG Crosslinker; Di(N-succinimidyl) glutarate; Bis(2,5-dioxopyrrolidin-1-yl) glutarate
IUPAC Name
bis(2,5-dioxopyrrolidin-1-yl) pentanedioate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCCC(=O)ON2C(=O)CCC2=O
InChI
InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChIKey
LNQHREYHFRFJAU-UHFFFAOYSA-N
Density
1.5±0.1 g/cm3
Solubility
Soluble in DMF, DMSO
Flash Point
247.2±31.5 °C
Index Of Refraction
1.572
LogP
-3.30
PSA
127.36000
Vapor Pressure
0.0±1.2 mmHg at 25°C
Biological Activity
DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Appearance
Off-white Powder
Purity
99.3 %
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Pictograms
Irritant
Signal Word
Warning
Boiling Point
485.1±55.0 °C at 760 mmHg
Form
Solid

DSG Crosslinker, a versatile chemical reagent integral to bioconjugation and biomolecular research, finds diverse applications across various domains. Here are four key applications:

Protein-Protein Interaction Studies: A commonly utilized tool, DSG Crosslinker plays a pivotal role in stabilizing and investigating protein-protein interactions. Through covalent bonding of interacting protein pairs, researchers can seize and scrutinize transient complexes that pose challenges in conventional study methodologies. This approach illuminates the dynamic nature and functional nuances of protein assemblies entwined in diverse biological phenomena.

Structural Biology: Within the realm of structural biology, DSG Crosslinker serves as a catalyst for exploring protein structures and conformations. By strategically linking sites within a protein or between protein subunits, scientists can unveil distance constraints pivotal in modeling and validating intricate three-dimensional structures. This methodological advancement proves invaluable in unraveling the convoluted architecture of biomolecular machinery.

Antibody Conjugation: Embraced widely in antibody conjugation endeavors for diagnostic and therapeutic ventures, DSG Crosslinker facilitates the linkage of antibodies to fluorophores, enzymes, or therapeutic agents. Through this strategic conjugation, researchers and healthcare practitioners fabricate precision tools tailored for imaging, detection, or disease intervention. This precision-enhancing strategy amplifies the specificity and efficacy of diagnostic assays and therapeutic modalities significantly.

Enzyme and Receptor Studies: Instrumental in the scrutiny of enzymes and receptors, DSG Crosslinker emerges as a critical agent in stabilizing and characterizing functional complexes. By crosslinking enzymes to their substrates or receptors to their interacting ligands, researchers unearth detailed insights into binding affinities, kinetics, and mechanistic underpinnings. This profound comprehension holds pivotal significance in the realms of drug discovery and unraveling the intricate pathways underpinning biochemical cascades.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Disuccinimidyl glutarate
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