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EMCC is a widely employed fluorescent probe in biomedicine that displays unparalleled proficiency in the detection and quantification of reactive oxygen species (ROS), encompassing hydroxyl radicals and singlet oxygen. Its versatile application extends to facilitating the monitoring of cell viability and apoptosis within the biomedical landscape. In addition, EMCC showcases its efficacy through the facilitation of diverse drug screening assays and the comprehensive analysis of oxidative stress-related diseases.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01488 | -- | $-- |
EMCC, short for Mal-AMCHC-N-Propargylamide, is a novel compound increasingly gaining attention in pharmaceutical research and development. This compound is characterized by its unique structure, which makes it a versatile tool in drug discovery, particularly in targeting diseases with complex biological pathways. EMCC is often used as a molecular probe due to its specificity in binding and modifying particular protein targets, a property attributable to its distinctive chemical moiety, the propargylamide group. This group allows EMCC to engage in click chemistry reactions, providing an efficient way to tag proteins and explore their functions within cellular processes.
In the realm of drug discovery, EMCC plays a pivotal role in the identification and validation of novel therapeutic targets. One of its significant applications is in the development of enzyme inhibitors, where EMCC acts by forming a covalent bond with the active site of the enzyme, effectively modulating its activity. This capability is particularly valuable in cancer research, where the inhibition of specific enzymes crucial for cancer cell proliferation can lead to the development of new cancer therapies. By utilizing EMCC as a covalent inhibitor, researchers can gain insights into enzyme biology and uncover potential avenues for drug development.
Moreover, EMCC’s role extends to the field of proteomics, where it is used to map the interactions between proteins and small molecules within cells. This application is crucial for understanding disease mechanisms at a molecular level and for identifying biomarkers for various diseases. EMCC facilitates the labeling of target proteins in complex biological samples, allowing for their subsequent isolation and identification. This capability is highly advantageous in the study of post-translational modifications and protein-protein interactions, areas that are pivotal in understanding cellular signaling pathways and disease progression.
Additionally, EMCC is utilized in the process of lead optimization during drug development. Its ability to form stable complexes with target proteins allows for detailed structural analyses, which are essential for designing more potent and selective drug candidates. By using EMCC, researchers can optimize drug-like properties such as solubility, permeability, and metabolic stability, thus enhancing the efficacy and safety profile of potential therapeutics. This aspect of EMCC’s application illustrates its importance not only in the early stages of drug discovery but also in the refinement of lead compounds to improve their therapeutic potential.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
