Catalog Number | Size | Price | Quantity |
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BADC-01966 | -- | $-- |
Fmoc-DAP-N3 is a protected derivative of diaminopropionic acid, commonly used in peptide synthesis and bioconjugation applications. Here are some key applications of Fmoc-DAP-N3:
Peptide Synthesis: Fmoc-DAP-N3 is employed in solid-phase peptide synthesis (SPPS) for creating complex peptides with functional groups. The azide group on Fmoc-DAP-N3 can be used for subsequent click chemistry reactions, enabling the attachment of various molecules to the peptide. This facilitates the production of peptides with tailored functionalities for research and therapeutic purposes.
Bioconjugation: In bioconjugation, Fmoc-DAP-N3 allows for the convenient attachment of peptides to other biomolecules such as proteins or nucleic acids through click chemistry. The azide group reacts with alkynes in a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction, forming a stable triazole linkage. This method is widely used in the development of biomolecule conjugates for drug delivery, imaging, and diagnostic applications.
Drug Development: Fmoc-DAP-N3 can be used in the development of drug candidates by linking active pharmaceutical ingredients (APIs) to targeting peptides. The azide functionality enables easy and efficient conjugation with various drug molecules, enhancing their delivery and specificity. This approach can improve the therapeutic index of drugs and reduce off-target effects.
Protein Engineering: In protein engineering, Fmoc-DAP-N3 can be incorporated into protein sequences to introduce reactive azide groups. This allows site-specific modification of proteins through click chemistry, facilitating the study of protein interactions and functions. Such modifications can be used to enhance protein stability, activity, or for the creation of novel protein-based materials.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.