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MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01095 | -- | $-- | Inquiry |
MAC glucuronide linker-2 is a versatile chemical linker predominantly used in the design of antibody-drug conjugates (ADCs). This linker is particularly valued for its stability in the bloodstream and its selective cleavage in the tumor microenvironment. The glucuronide moiety allows for the controlled release of cytotoxic drugs, ensuring that the therapeutic agent is released only at the target site, such as cancer cells. This targeted drug delivery helps minimize systemic toxicity while enhancing the effectiveness of the drug against tumors, making MAC glucuronide linker-2 a key component in the development of advanced ADC therapies for cancer treatment.
Another important application of MAC glucuronide linker-2 is in the development of targeted gene therapies. The linker is being explored for its potential to deliver nucleic acid-based therapeutics, such as siRNA or gene-editing tools like CRISPR-Cas9, directly to specific tissues or cells. By using the glucuronide linker, these therapeutic agents can be conjugated to targeting moieties, such as antibodies or peptides, ensuring that the therapeutic material reaches the intended cells. This approach improves the precision and efficiency of gene therapies, reducing off-target effects and enhancing therapeutic outcomes in genetic disorders.
In addition to its applications in ADCs and gene therapy, MAC glucuronide linker-2 is also being studied for its potential use in the delivery of immunomodulatory agents. The linker can be attached to small molecules that modulate the immune response, such as checkpoint inhibitors or cytokines, allowing for their targeted release at sites of inflammation or immune activation. This targeted delivery holds promise in the treatment of autoimmune diseases, inflammatory conditions, and even in enhancing the efficacy of cancer immunotherapies. The use of MAC glucuronide linker-2 for precise delivery of immunomodulatory agents could significantly improve therapeutic outcomes while minimizing unwanted systemic effects.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
