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m-PEG4-NHS ester is a PEG derivative containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00683 | -- | $-- | Inquiry |
mPEG3-CH2CH2COONHS ester, a versatile reagent, finds extensive utility in various biochemical applications, particularly in the realms of protein conjugation and surface modification. Here are four key applications of mPEG3-CH2CH2COONHS ester:
Protein Conjugation: Widely leveraged in bioconjugation, mPEG3-CH2CH2COONHS ester plays a pivotal role in attaching polyethylene glycol (PEG) chains to proteins and peptides. This crucial modification elevates the solubility and stability of proteins, often resulting in diminished immunogenicity and prolonged circulation within living organisms. Such enhancements are instrumental in the development of therapeutic proteins and peptides, enriching their pharmacokinetic profiles with valor.
Surface Modification: Instrumental in the realm of nanoparticles and biomaterials, mPEG3-CH2CH2COONHS ester is utilized for surface modification. By introducing PEG groups, this ester imparts hydrophilicity while fostering antifouling characteristics, thereby mitigating non-specific protein adsorption and cellular interactions. This application is paramount for bolstering the performance of medical devices, drug delivery systems, and biosensors.
Immobilization Techniques: In the field of biotechnology, mPEG3-CH2CH2COONHS ester serves as a crucial agent in immobilizing biomolecules onto solid platforms. This process lays the foundation for the development of cutting-edge biosensors and bioassays by furnishing a stable and functional stage for biological interactions. The activated ester group efficiently engages with amine-containing molecules, facilitating robust and specific attachments with finesse.
Hydrogel Formation: Embracing the synthesis of hydrogels, the versatile ester brings forth PEGylation to elevate the mechanical properties and biocompatibility of the gel matrix. These hydrogels find applications in tissue engineering and regenerative medicine, crafting an environment conducive to cell growth and tissue regeneration. The PEGylation process plays a crucial role in governing the hydrogel’s swelling behavior and degradation rate, tailoring its characteristics to meet specific biomedical requisites with precision.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
