N-(5-Hydroxypentyl)maleimide - CAS 180608-78-0

N-(5-Hydroxypentyl)maleimide - CAS 180608-78-0 Catalog number: BADC-00996

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N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) ).

Category
ADCs Linker
Product Name
N-(5-Hydroxypentyl)maleimide
CAS
180608-78-0
Catalog Number
BADC-00996
Molecular Formula
C9H13NO3
Molecular Weight
183.20

Ordering Information

Catalog Number Size Price Quantity
BADC-00996 -- $--
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Description
N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) ).
Synonyms
1-(5-hydroxypentyl)pyrrole-2,5-dione
IUPAC Name
1-(5-hydroxypentyl)pyrrole-2,5-dione
Canonical SMILES
C1=CC(=O)N(C1=O)CCCCCO
InChI
InChI=1S/C9H13NO3/c11-7-3-1-2-6-10-8(12)4-5-9(10)13/h4-5,11H,1-3,6-7H2
InChIKey
YTIZONIKDWSRFR-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Biological Activity
N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1]
Appearance
Solid
Purity
>99.6%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: N-(5-Hydroxypentyl)maleimide
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