Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-00004 | Colchicine | 64-86-8 |
| Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 μM). It inhibits the growth of MCF-7 human breast carcinoma cells and has anti-inflammatory activity. Colchicine can lower body temperature, inhibit the respiratory center, enhance the effect of sympathomimetic drugs, constrict blood vessels, and raise blood pressure. | Inquiry | |
| BADC-00008 | Val-Cit-PAB-MMAE | 644981-35-1 |
| Val-Cit-PAB-MMAE, a tubulin polymerase inhibitor, is a drug-linker conjugate for ADC. It contains an ADC linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE. | Inquiry | |
| BADC-00009 | DM1-SMCC | 1228105-51-8 |
| DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR. | Inquiry | |
| BADC-00010 | DM1-SPP | 452072-20-7 |
| DM1 with a reactive linker SPP, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR. | Inquiry | |
| BADC-00011 | DM4-SPDP | 2245698-48-8 |
| DM4 with a reactive linker SPDP, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. | Inquiry | |
| BADC-00012 | DM4-SPDB | 1626359-62-3 |
| DM4 with a reactive linker SPDB, which can react with antibody to make antibody drug conjugate. DM4 can bind to tubulin at or near the vinblastine-binding site. | Inquiry | |
| BADC-00016 | Vat-Cit-PAB-MMAD | 1415329-13-3 |
| Vat-Cit-PAB-MMAD is a protective group conjugated MMAD, MMAD is a toxin payload in antibody drug conjugate. | Inquiry | |
| BADC-00021 | DM4-SMe | 796073-68-2 |
| DM4-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). . | Inquiry | |
| BADC-00022 | DM3-SMe | 796073-70-6 |
| DM3-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC). . | Inquiry | |
| BADC-00029 | MC-Val-Cit-PAB-MMAE | 646502-53-6 |
| MC-Val-Cit-PAB-MMAE is a potent tubulin inhibitor (MMAE), Val-Cit-PAB-MMAE is an antibody drug conjugate. | Inquiry | |
| BADC-00033 | PNU-159682 | 202350-68-3 |
| PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes. It is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity, and shows >3,000-fold cytotoxic than its parent compound (MMDX and doxorubicin). It is a more potent and well tolerated ADC cytotoxin than doxorubicin. | Inquiry | |
| BADC-00036 | Triptolide | 38748-32-2 |
| Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It has immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is an NF-κB activation inhibitor. | Inquiry | |
| BADC-00037 | Methotrexate | 59-05-2 |
| Methotrexate(WR19039; CL14377) can interfere with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. | Inquiry | |
| BADC-00038 | Doxorubicin hydrochloride | 25316-40-9 |
| Doxorubicin is an anthracycline antibiotic with antineoplastic activity produced by the bacterium Streptomyces peucetius var. Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. | Inquiry | |
| BADC-00040 | Dolastatin 10 | 110417-88-4 |
| Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibiting microtubule assembly. | Inquiry | |
| BADC-00041 | Daunorubicin hydrochloride | 23541-50-6 |
| Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. | Inquiry | |
| BADC-00045 | Auristatin F | 163768-50-1 |
| Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. | Inquiry | |
| BADC-00086 | Mertansine | 139504-50-0 |
| Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine. | Inquiry | |
| BADC-00088 | Nemorubicin | 108852-90-0 |
| Nemorubicin, is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. | Inquiry | |
| BADC-00089 | Calicheamicin | 108212-75-5 |
| Calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, The main component is calicheamicin γ1. It has strong anti-Gram-positive bacteria activity and anti-tumor effect. | Inquiry |
