trans-4-Hydroxy-D-proline HCl - CAS 142347-81-7

trans-4-Hydroxy-D-proline HCl - CAS 142347-81-7 Catalog number: BADC-01924

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trans-4-Hydroxy-D-proline HCl is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.

Category
ADCs Linker
Product Name
trans-4-Hydroxy-D-proline HCl
CAS
142347-81-7
Catalog Number
BADC-01924
Molecular Formula
C5H10ClNO3
Molecular Weight
167.59
trans-4-Hydroxy-D-proline HCl

Ordering Information

Catalog Number Size Price Quantity
BADC-01924 -- $--
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Description
trans-4-Hydroxy-D-proline HCl is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
Synonyms
(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
IUPAC Name
(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid;hydrochloride
Canonical SMILES
C1C(CNC1C(=O)O)O.Cl
InChI
InChI=1S/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4+;/m0./s1
InChIKey
YEJFFQAGTXBSTI-RFKZQXLXSA-N
Purity
95%
Quantity
Data not available, please inquire.
Boiling Point
368.6°C at 760mmHg
1.Enantioselective Oxetane Ring Opening with Chloride: Unusual Use of Wet Molecular Sieves for the Controlled Release of HCl.
Yang W1, Wang Z1, Sun J2. Angew Chem Int Ed Engl. 2016 Apr 28. doi: 10.1002/anie.201601844. [Epub ahead of print]
An unprecedented enantioselective oxetane opening with chloride provides access to a range of highly functionalized three-carbon building blocks. The excellent enantiocontrol is enabled by not only a new catalyst, but also by the unusual use of wet molecular sieves for the controlled release of HCl.
2.Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets.
Bogusz AM1, Bagg A1. Leuk Lymphoma. 2016 Apr 27:1-23. [Epub ahead of print]
Small B-cell lymphomas and leukemias (SBCLs) are a clinically, morphologically, immunophenotypically and genetically heterogeneous group of clonal lymphoid neoplasms, including entities such as chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma (MCL), follicular lymphoma (FL), lymphoplasmacytic lymphoma (LPL), marginal zone lymphoma (MZL) and hairy cell leukemia (HCL). The pathogenesis of some of these lymphoid malignancies is characterized by distinct translocations, for example t(11;14) in the majority of cases of MCL and t(14;18) in most cases of FL, whereas other entities are associated with a variety of recurrent but nonspecific numeric chromosomal abnormalities, as exemplified by del(13q14), del(11q22), and +12 in CLL, and yet others such as LPL and HCL that lack recurrent or specific cytogenetic aberrations. The recent surge in next generation sequencing (NGS) technology has shed more light on the genetic landscape of SBCLs through characterization of numerous driver mutations including SF3B1 and NOTCH1 in CLL, ATM and CCND1 in MCL, KMT2D and EPHA7 in FL, MYD88 (L265P) in LPL, KLF2 and NOTCH2 in splenic MZL (SMZL) and BRAF (V600E) in HCL.
3.Acidity of Strong Acids in Water and Dimethyl Sulfoxide.
Trummal A, Lipping L, Kaljurand I, Koppel IA, Leito I. J Phys Chem A. 2016 Apr 26. [Epub ahead of print]
Careful analysis and comparison of the available acidity data of HCl, HBr, HI, HClO4 and CF3SO3H in water, DMSO and gas-phase has been carried out. The data include experimental and computational pKa and gas-phase acidity data from the literature, as well as high-level computations using different approaches (including the W1 theory) carried out in this work. As a result of the analysis, for every acid in every medium a recommended acidity value is presented. In some cases the currently accepted pKa values were revised by more than 10 orders of magnitude.
4.The effect of thermal processing on the behaviour of peanut allergen peptide targets used in multiple reaction monitoring mass spectrometry experiments.
Sayers RL1, Johnson PE1, Marsh JT1, Barran P2, Brown H3, Mills EN1. Analyst. 2016 Apr 26. [Epub ahead of print]
Mass spectrometry-based methods offer an alternative means of determining allergens in foods. Whilst targeted methods are likely to offer the most robust approach for detection and quantification, little is known about how food processing may affect the behaviour of peptide targets. A systematic study has been undertaken to investigate the effects of thermal processing (boiling, roasting, frying) on the behaviour of a suite of peanut peptide targets representing the major clinically-relevant allergens. Initially the effect of thermal processing on protein extractability was investigated and a mass spectrometry-compatible buffer identified comprising 50 mM Tris-HCl, pH 8.8 containing 50 mM dithiothreitol and 0.04% (w/v) acid labile detergent which was able to extract 45-100% of protein from raw, boiled, roasted and fried peanuts using sonication at 60 °C. Eight peptide targets were identified including two peptides from each cupin allergen, Ara h1 and Ara h3 and four peptides from the prolamin superfamily allergens Ara h2, 6 and 7.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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