cis-4-Hydroxy-D-proline HCl - CAS 77449-94-6

cis-4-Hydroxy-D-proline HCl - CAS 77449-94-6 Catalog number: BADC-01928

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cis-4-Hydroxy-D-proline HCl is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.

Category
ADCs Linker
Product Name
cis-4-Hydroxy-D-proline HCl
CAS
77449-94-6
Catalog Number
BADC-01928
Molecular Formula
C5H10ClNO3
Molecular Weight
167.59
cis-4-Hydroxy-D-proline HCl

Ordering Information

Catalog Number Size Price Quantity
BADC-01928 -- $--
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Description
cis-4-Hydroxy-D-proline HCl is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker.
Synonyms
cis-4-Hydroxy-D-proline hydrochloride; rel-(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
IUPAC Name
(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid;hydrochloride
Canonical SMILES
C1C(CNC1C(=O)O)O.Cl
InChI
InChI=1S/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m1./s1
InChIKey
YEJFFQAGTXBSTI-VKKIDBQXSA-N
Melting Point
114-116°C
Purity
95%
Boiling Point
368.6°C at 760 mmHg

Cis-4-Hydroxy-D-proline HCl, a derivative of proline frequently employed in biochemical and pharmaceutical research, has diverse applications. Here are four key applications:

Collagen Research: Playing a pivotal role in collagen synthesis exploration, cis-4-Hydroxy-D-proline HCl acts as a vital component. Scientists utilize this compound to delve into the impact of proline hydroxylation on the triple-helix structure of collagen. This research is imperative for unraveling the complexities of connective tissue disorders and advancing treatment methodologies.

Pharmaceutical Development: At the forefront of drug design, cis-4-Hydroxy-D-proline HCl serves as a crucial chiral starting material for synthesizing various pharmaceutical compounds. Its use contributes to the creation of drugs that exhibit enhanced efficacy and selectivity, particularly collagenase enzyme inhibitors. This application is especially significant in developing medications for conditions like osteoarthritis and other degenerative ailments.

Peptide Synthesis: With a focus on generating cyclic peptides and intricate peptide structures, cis-4-Hydroxy-D-proline HCl finds utility in peptide synthesis endeavors. The hydroxyl group present in this compound boosts the solubility and stability of peptides, rendering them more suitable for therapeutic applications. Researchers leverage this compound to explore the potential of novel peptide-based drugs and therapeutic agents.

Protein Engineering: Delving into protein engineering studies, scientists incorporate cis-4-Hydroxy-D-proline HCl into proteins to investigate the influence of proline hydroxylation on protein folding, stability, and function. This compound aids in elucidating the significance of post-translational modifications in protein biochemistry. These profound insights guide the design of proteins with augmented properties for both industrial and medical usage.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: cis-4-Hydroxy-D-proline HCl
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