1-(2,5-dioxopyrrolidin-1-yloxy)-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid, a versatile compound renowned for its myriad applications in bioconjugation and protein chemistry. Here are four key applications presented with high perplexity and burstiness:
Protein Labeling: By forming stable covalent bonds with amino acid residues, this compound serves as a vital tool for labeling proteins with a diverse array of probes and tags. Researchers leverage this capability to track and analyze protein behavior within intricate biological systems, enriching their studies in proteomics and structural biology.
Antibody-Drug Conjugates (ADCs): In the dynamic field of ADC development, this compound plays a pivotal role as a linker, facilitating the attachment of cytotoxic drugs to antibodies. The stability of the linkage ensures precise delivery of the drug to targeted cancer cells, minimizing off-target effects and bolstering the efficacy and specificity of cancer treatment strategies.
Biosensor Development: Through its interaction with biomolecules like enzymes and antibodies, this compound contributes to the creation of advanced biosensors with heightened sensitivity and specificity. These bioconjugates enhance the performance of biosensors utilized in diagnostics and environmental monitoring, enabling swift and accurate detection of diverse analytes.
Pulldown Assays: In the realm of pulldown assays, this compound serves as a cornerstone for immobilizing proteins onto solid supports, facilitating the isolation and elucidation of pivotal protein-protein interactions. This technique plays a critical role in dissecting cellular pathways, aiding researchers in uncovering potential therapeutic targets and biomarkers crucial for advancing precision medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.