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NO2-SPDMV-sulfo is a small molecule compound in the biomedical field. It is a potent drug that shows significant efficacy by selectively targeting key drug receptors. It has shown great promise in halting the progression of certain malignancies and inflammatory diseases.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00465 | -- | $-- |
Bioconjugation Reagent for Protein Modification: 1-(4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is extensively used as a bioconjugation reagent for protein modification. Its unique chemical structure, featuring a pyridinyl-disulfide moiety and a dioxopyrrolidine-sulfonic acid group, allows for selective and efficient modification of thiol groups in proteins. This specificity makes it an ideal choice for targeted protein labeling, enabling researchers to study protein interactions and functions with high precision. Such modifications are crucial in proteomics, structural biology, and pharmaceutical research, where understanding protein dynamics and developing protein-based therapeutics are of paramount importance.
Crosslinking Agent for Antibody-Drug Conjugates (ADCs): This compound serves as an effective crosslinking agent in the synthesis of antibody-drug conjugates (ADCs). Its dual reactive sites facilitate the stable attachment of cytotoxic drugs to antibodies, enhancing the therapeutic efficacy and targeting capabilities of ADCs. The disulfide bond in its structure allows for controlled drug release in the reducing environment of cancer cells, improving the selectivity and reducing off-target effects. This property is highly valuable in oncology, where precise delivery of cytotoxic agents to tumor cells is critical for minimizing side effects and maximizing therapeutic outcomes.
Polymer Surface Functionalization: 1-(4-methyl-4-((5-nitropyridin-2-yl)disulfanyl)pentanoyloxy)-2,5-dioxopyrrolidine-3-sulfonic acid is also utilized for the functionalization of polymer surfaces. The sulfonic acid group enhances the solubility and reactivity of the compound, enabling efficient grafting onto a variety of polymer substrates. This functionalization is particularly beneficial in biomedical applications, such as developing biocompatible coatings for medical devices or creating hydrophilic surfaces for improved protein adsorption and cell adhesion. These modified polymer surfaces can be used in biosensors, tissue engineering, and drug delivery systems, providing versatile platforms for advanced biomedical research and development.
Site-Specific Drug Delivery Systems: The compound's structural characteristics make it a valuable tool in the design of site-specific drug delivery systems. The disulfide bond can be engineered to release therapeutic agents in response to specific intracellular environments, such as the high glutathione levels found in cancer cells. This targeted release mechanism improves the therapeutic index of the drug while minimizing systemic toxicity. In addition, the sulfonic acid group can enhance the solubility and bioavailability of the conjugated drug, making it a promising candidate for developing novel drug delivery platforms aimed at treating various diseases with high precision and reduced side effects.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
