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3-Azidopropionic Acid Sulfo-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01051 | -- | $-- |
3-Azidopropionic Acid Sulfo-NHS ester, a versatile chemical reagent, finds diverse applications in bioconjugation and labeling techniques. Here are four key applications intricately presented with high perplexity and burstiness:
Protein Labeling: A cornerstone of biochemistry, 3-Azidopropionic Acid Sulfo-NHS ester is instrumental in labeling proteins with azide groups, paving the way for bio-orthogonal click chemistry reactions. This sophisticated technique allows for the attachment of a myriad of reporter molecules, ranging from fluorescent dyes to biotin, onto proteins. By engaging in protein labeling, researchers unlock the ability to delve into the intricate realm of protein-protein interactions and localization dynamics within biological systems.
Surface Modification: Embarking on cutting-edge biomaterial science, researchers leverage the power of this ester to modify surfaces with azide groups, setting the stage for further functionalization through click chemistry. This innovative approach enables the creation of biofunctional surfaces tailored for diverse applications such as biosensors, tissue engineering scaffolds, and drug delivery systems. The resultant surfaces display a remarkable ability to interact selectively with target molecules, thus enhancing the functionality and specificity of the biomaterial.
Peptide and Oligonucleotide Conjugation: Pushing the boundaries of biomolecular research, 3-Azidopropionic Acid Sulfo-NHS ester plays a critical role in introducing azide groups into peptides and oligonucleotides, facilitating their conjugation to other biomolecules via click chemistry. This methodical process forms the foundation for creating intricate biomolecular assemblies, expanding the toolkit for studying interactions, and advancing the development of novel therapeutics.
Cross-Linking Studies: Delving into the realm of protein-protein interactions, researchers employ 3-Azidopropionic Acid Sulfo-NHS ester to investigate intricate interaction networks. By introducing a reactive azide group into one protein and a complementary alkyne group into another, researchers orchestrate the formation of stable, covalently bonded complexes under click chemistry conditions. This methodological approach is paramount for unraveling the complexities of protein complexes and mapping intricate protein interaction networks.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
