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3-azidopropanoate-N-hydroxysuccinimide ester is a small molecule reagent. As a versatile reactive reagent, it has a significant impact on bioconjugation and cross-linking applications. It is deeply embedded in the synthetic mechanism of drug delivery systems, effectively achieving precise targeted release of therapeutic drugs.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00412 | -- | $-- |
3-azidopropanoate-N-hydroxysuccinimide ester is a versatile chemical reagent with several important applications in bioconjugation and molecular biology. Here are some key applications of 3-azidopropanoate-N-hydroxysuccinimide ester:
Protein Labeling: 3-azidopropanoate-N-hydroxysuccinimide ester is commonly used to label proteins with azide groups. This allows for subsequent "click chemistry" reactions with alkyne-containing molecules, enabling the attachment of various probes such as fluorescent tags or biotin. This technique is essential for studying protein interactions, localization, and function.
Antibody Conjugation: This reagent can be used to conjugate antibodies to a variety of molecules, enhancing their functionality in detection and therapy. By attaching drugs, toxins, or imaging agents to antibodies, it’s possible to create targeted treatments for diseases such as cancer. This application is pivotal in the development of antibody-drug conjugates and diagnostic tools.
Immobilization of Biomolecules: 3-azidopropanoate-N-hydroxysuccinimide ester is employed to immobilize biomolecules like enzymes and DNA onto surfaces. By attaching these molecules to solid supports, scientists can create bioactive surfaces for use in biosensors, microarrays, and biochips. This facilitates the high-throughput analysis of biological samples and the development of diagnostic assays.
Synthetic Biology: In synthetic biology, this ester can be used to introduce azide groups into biomolecules, which can then undergo orthogonal chemical reactions. This enables the construction of complex bio-molecular architectures and the design of novel biological systems. These capabilities are crucial for the advancement of synthetic biology applications, including the creation of artificial cells and new metabolic pathways.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
