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| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01037 | -- | $-- |
Acid-PEG3-SS-PEG3-acid is a bifunctional polyethylene glycol (PEG) linker used in various bioconjugation and drug delivery applications. Here are some key applications of Acid-PEG3-SS-PEG3-acid:
Antibody-Drug Conjugates (ADCs): Acid-PEG3-SS-PEG3-acid is used in the development of ADCs by linking cytotoxic drugs to antibodies. The disulfide bond in the linker is cleavable in the reductive environment of cancer cells, ensuring targeted release of the drug. This targeted delivery system minimizes damage to healthy tissues and enhances the efficacy of cancer treatment.
Protein Modification: This bifunctional linker is used to modify proteins and peptides to improve their pharmacokinetic properties, such as solubility and stability. By attaching Acid-PEG3-SS-PEG3-acid to therapeutic proteins, researchers can reduce immunogenicity and prolong circulation time in the bloodstream. This modification aids in the development of more effective biopharmaceuticals.
Nanoparticle Functionalization: Acid-PEG3-SS-PEG3-acid can be employed to functionalize nanoparticles for improved drug delivery and diagnostic imaging. The PEG segments enhance the biocompatibility and circulation time of nanoparticles, while the disulfide linker allows for controlled release of the therapeutic payload. This approach is used to create targeted nanocarriers that can deliver drugs to specific tissues or cells.
Surface Coating: In biosensor development, Acid-PEG3-SS-PEG3-acid is used to coat sensor surfaces, providing a non-fouling layer that prevents non-specific binding. The PEG linker enhances the biocompatibility and sensitivity of the sensors, improving their performance in complex biological samples. This application is crucial for the development of reliable diagnostic and analytical devices.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
