AcLys-PABC-VC-Aur0101 intermediate-1 - CAS 1609108-48-6

AcLys-PABC-VC-Aur0101 intermediate-1 - CAS 1609108-48-6 Catalog number: BADC-01741

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AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
AcLys-PABC-VC-Aur0101 intermediate-1
CAS
1609108-48-6
Catalog Number
BADC-01741
Molecular Formula
C41H53N7O8
Molecular Weight
771.90

Ordering Information

Catalog Number Size Price Quantity
BADC-01741 -- $--
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Description
AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
N2-acetyl-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysyl-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-omithinamide
IUPAC Name
9H-fluoren-9-ylmethyl N-[(5S)-5-acetamido-6-[[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-6-oxohexyl]carbamate
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)C(CCCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)NC(=O)C
InChI
InChI=1S/C41H53N7O8/c1-25(2)36(39(53)47-35(16-10-22-43-40(42)54)37(51)46-28-19-17-27(23-49)18-20-28)48-38(52)34(45-26(3)50)15-8-9-21-44-41(55)56-24-33-31-13-6-4-11-29(31)30-12-5-7-14-32(30)33/h4-7,11-14,17-20,25,33-36,49H,8-10,15-16,21-24H2,1-3H3,(H,44,55)(H,45,50)(H,46,51)(H,47,53)(H,48,52)(H3,42,43,54)/t34-,35-,36-/m0/s1
InChIKey
FUKMTJHGXXYHHK-KVBYWJEESA-N

AcLys-PABC-VC-Aur0101 intermediate-1 plays a pivotal role in the synthesis of drug conjugates, particularly antibody-drug conjugates (ADCs). Explore its diverse applications with a touch of high perplexity and burstiness:

Drug Development: Fueling the frontier of targeted cancer therapies, AcLys-PABC-VC-Aur0101 intermediate-1 acts as the linchpin in ADC creation. By linking antibodies to cytotoxic drugs, it orchestrates precise drug delivery to cancer cells, minimizing collateral damage and heightening therapeutic efficacy.

Cancer Research: In the realm of oncology, this compound stands as a cornerstone for probing the effectiveness and safety of novel anticancer agents. Leveraging AcLys-PABC-VC-Aur0101 intermediate-1, researchers sculpt experimental models, unraveling drug behaviors and mechanisms in preclinical settings, enriching our insights into ADC functionality.

Bioconjugation Studies: Amid the tapestry of bioconjugation, AcLys-PABC-VC-Aur0101 intermediate-1 emerges as a catalyzing force for innovation. Scientists wield this compound to forge new pathways of biomolecule linkage, unveiling avant-garde conjugation techniques with vast implications in biotechnological and pharmaceutical arenas, ushering in a new era of drug delivery systems and diagnostic modalities.

Pharmaceutical Manufacturing: At the core of ADC production lies the indispensable role of AcLys-PABC-VC-Aur0101 intermediate-1. Serving as a linchpin in large-scale synthesis, this compound ensures the uniformity and resilience of the final product, upholding stringent quality benchmarks for clinical application, underpinning the foundation of robust ADC manufacturing processes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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