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Ald-PEG4-NHS ester is a non-cleavable 4-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00397 | -- | $-- | Inquiry |
Ald-PEG4-NHS ester is a modified polyethylene glycol (PEG) linker with an N-hydroxysuccinimide (NHS) ester reactive group, widely used in bioconjugation applications. Here are some key applications of Ald-PEG4-NHS ester:
Bioconjugation: Ald-PEG4-NHS ester is extensively used in the bioconjugation of proteins, peptides, and antibodies. The NHS ester reacts efficiently with primary amines on biomolecules, forming stable amide bonds. This allows for the attachment of functional groups or labels, facilitating various biochemical assays and diagnostic applications.
Drug Delivery: In the field of drug delivery, Ald-PEG4-NHS ester can be used to modify the surface of nanoparticles and other carriers. The PEGylation process improves the pharmacokinetics and bio-distribution of therapeutic agents by enhancing their solubility and reducing immunogenicity. This leads to more effective and targeted drug delivery systems.
Surface Modification: Ald-PEG4-NHS ester is employed in the surface modification of biomaterials and medical devices. By attaching PEG chains to surfaces, it reduces non-specific protein adsorption and cellular adhesion, increasing biocompatibility and reducing potential for adverse reactions. This application is crucial in the development of implants, biosensors, and other medical devices.
Cross-Linking Reagents: As a cross-linking reagent, Ald-PEG4-NHS ester is used to create hydrogel networks and other polymeric structures. The PEG linkers provide flexibility and hydrophilicity, making them ideal for tissue engineering and regenerative medicine applications. These hydrogels can be tailored to support cell growth and tissue formation, enhancing their utility in biomedical research and therapy.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
