Ald-PEG23-SPDP

Ald-PEG23-SPDP Catalog number: BADC-01200

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Category
ADCs Linker
Product Name
Ald-PEG23-SPDP
Catalog Number
BADC-01200
Molecular Formula
C64H111N3O26S2
Molecular Weight
1402.71

Ordering Information

Catalog Number Size Price Quantity
BADC-01200 -- $--
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Solubility
10 mm in DMSO
Purity
98.0%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

Ald-PEG23-SPDP, a versatile crosslinker merging a polyethylene glycol (PEG) spacer with a cleavable disulfide bond, is a cornerstone in various bioconjugation scenarios. Here, explore four key applications presented with a high level of perplexity and burstiness:

Drug Delivery: Ald-PEG23-SPDP is harnessed by researchers for conjugating drugs with targeting molecules, enhancing the precision and efficacy of therapeutic interventions. The PEG spacer bolsters solubility and stability within the drug conjugate, while the cleavable disulfide bond governs controlled release within the designated environment. This advanced technology holds tremendous value in shaping targeted cancer therapies and revolutionizing precision medicines, reshaping the landscape of drug delivery.

Protein-Protein Crosslinking: In the realm of biochemical exploration, Ald-PEG23-SPDP plays a pivotal role in streamlining the crosslinking of proteins, facilitating the scrutiny of protein interactions. The PEG linker preserves the biological functionality of proteins by mitigating steric hindrances, while the reducible disulfide bond allows for subsequent separation if required. This application serves as a cornerstone for unraveling protein complexes and mapping intricate interaction networks, shedding light on the complex domain of protein interactions.

Antibody Conjugation: Ald-PEG23-SPDP emerges as a highly effective tool for modifying antibodies to create antibody-drug conjugates (ADCs) or tagging antibodies with detection markers. PEGylation diminishes immunogenicity and extends circulation duration, while the disulfide bond ensures controlled release of the drug or marker within target cells. Widely embraced in therapeutic and diagnostic settings, this technology offers remarkable specificity and mitigates adverse effects, heralding a transformative era in antibody conjugation strategies.

Biosensor Development: In the realm of biosensors, Ald-PEG23-SPDP plays a pivotal role in anchoring biorecognition elements like enzymes or antibodies onto sensor surfaces. The PEG spacer safeguards the functionality of the recognition element by creating a flexible and hydrophilic environment. The cleavable bond enables reversible or refreshed responses, making this crosslinker ideal for reusable and dynamic biosensing platforms.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Ald-PEG23-SPDP
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